ArticleDevelopment (Cambridge, England)2017
Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion.
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Spatially resolved fetal and maternal cell contributions to severe preeclampsia across gestation.Science advances · 2026Article
- Inhibition of placental trophoblast fusion by guanylate-binding protein 5.Science advances · 2025Article
- Single-nucleus transcriptional profiling of the placenta reveals the syncytiotrophoblast stress response to COVID-19.American journal of obstetrics and gynecology · 2025Article
- Extracellular Vesicles Alter Trophoblast Function in Pregnancies Complicated by COVID-19.Journal of extracellular vesicles · 2025Article
- Evaluating the association between placenta DNA methylation and cognitive functions in the offspring.Translational psychiatry · 2024Article
- Placental Transcriptome Analysis in Connection with Low Litter Birth Weight Phenotype (LBWP) Sows.Genes · 2024Article
- Construction and analysis of pseudogene-related ceRNA network in breast cancer.Scientific reports · 2023Article
- Insulin-like growth factor 1 ameliorates pre-eclampsia by inhibiting zinc finger E-box binding homeobox 1 by up-regulation of microRNA-183.Journal of cellular and molecular medicine · 2023Article
- Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia.Lipids in health and disease · 2023Article
- Regionally distinct trophoblast regulate barrier function and invasion in the human placenta.eLife · 2022Article
- Article
- Quantitative proteomic analysis of serum-purified exosomes identifies putative pre-eclampsia-associated biomarkers.Clinical proteomics · 2022Article
- PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percreta†.Biology of reproduction · 2021Article
- Molecular and immunological developments in placentas.Human immunology · 2021Review
- First trimester serum PAPP-A is associated with placenta accreta: a retrospective study.Archives of gynecology and obstetrics · 2021Review
- Endometrial Organoids: A New Model for the Research of Endometrial-Related Diseases†.Biology of reproduction · 2020Review
- Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features.Clinical epigenetics · 2020Article
- Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation.Environmental health : a global access science source · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Pre-eclampsia (PE), which affects ∼8% of first pregnancies, is associated with faulty placentation. Extravillous cytotrophoblasts (CTBs) fail to differentiate properly, contributing to shallow uterine invasion and deficient spiral artery remodeling. We studied the effects of severe PE (sPE) on the smooth chorion portion of the fetal membranes. The results showed a significant expansion of the CTB layer. The cells displayed enhanced expression of stage-specific antigens that extravillous CTBs normally upregulate as they exit the placenta. Transcriptomics revealed the dysregulated expression of many genes (e.g. placental proteins, markers of oxidative stress). We confirmed an sPE-related increase in production of PAPPA1, which releases IGF1 from its binding protein. IGF1 enhanced proliferation of smooth chorion CTBs, a possible explanation for expansion of this layer, which may partially compensate for the placental deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.