Evidence map›Paper›PMID 28232487›Full record

ArticleThe Journal of biological chemistry2017

Fatty acid synthase inhibits the

Jennifer A Groves, Austin O Maduka, Robert N O'Meally, Robert N Cole, Natasha E Zachara

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Mammalian fatty acid synthase andBiochemistry and biophysics reports · 2026
    Article
  4. Article
  5. O-GlcNAc informatics: advances and trends.Analytical and bioanalytical chemistry · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Cells · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Biomolecules · 2022
    Article
  18. Thermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome.Journal of the American Chemical Society · 2022
    Article
  19. Article
  20. A nexus of lipid andFrontiers in endocrinology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jennifer A GrovesFrom the Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185.
Austin O MadukaFrom the Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185.
Robert N O'MeallyFrom the Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185.
Robert N ColeFrom the Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185.
Natasha E ZacharaFrom the Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, nzachara@jhmi.edu.
Johns Hopkins Medicine · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
The MARC U*STAR Program at UMBCT34GM008663 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI ROBINSON, PHYLLIS R · 1997 to 2019
$21.9M
Shared Resource CoresP01HL107153 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ZHANG, HUI · 2011 to 2017
$16.8M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
Request for Zeiss LSM 510 MP Multiphoton Imaging SystemS10RR024550 · NCRR · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2008 to 2008
$500k
Characterization of the O-GlcNAc-Binding Protein p32F31AG047724 · NIA · JOHNS HOPKINS UNIVERSITY · PI GROVES, JENNIFER ALISE · 2014 to 2017
$127k
NCI NIH HHS P30 CA006973NCRR NIH HHS S10 RR024550NHLBI NIH HHS P01 HL107153NIA NIH HHS F31 AG047724NIDDK NIH HHS P30 DK089502NIGMS NIH HHS T34 GM008663
6 · The paper itself

Abstract

The dynamic post-translational modification

Indexed as

Oxidative StressAnimalsBiotinylationCatalysisCatalytic DomainCell Line, TumorFatty Acid SynthasesFilaminsFluorescent Antibody Technique, IndirectGlycoproteinsHSC70 Heat-Shock ProteinsHumansIsoenzymesMaleMiceMice, Inbred C57BLFatty Acid SynthasesFilaminsFLNA protein, humanFlnA protein, mouseGlycoproteinsHSC70 Heat-Shock ProteinsHSPA8 protein, humanHspa8 protein, mouseIsoenzymesN-AcetylglucosaminyltransferasesO-GlcNAc transferaseBioIDfatty acid synthase (FAS)glycoproteinmgea5O-GlcNAcylationoxidative stresspost-translational modification (PTM)protein-protein interactionproteomicssignal transduction

Identifiers

PMID28232487
PMCPMC5399103
OpenAlexW2589903105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.