Evidence map›Paper›PMID 28232469›Full record

ArticleThe Journal of experimental medicine2017

A myeloid tumor suppressor role for

Robert F Stanley, Richard T Piszczatowski, Boris Bartholdy, Kelly Mitchell, Wendy M McKimpson, Swathi Narayanagari, Dagmar Walter, Tihomira I Todorova, Cassandra Hirsch, Hideki Makishima and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Anticancer Activity ofNutrients · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Robert F StanleyDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0003-3643-8592
Richard T PiszczatowskiDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0002-1250-683X
Boris BartholdyDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Kelly MitchellDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Wendy M McKimpsonDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Swathi NarayanagariDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Dagmar WalterDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Tihomira I TodorovaDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Cassandra HirschDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland, OH 44195.ORCID 0000-0002-2174-6560
Hideki MakishimaDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland, OH 44195.
Britta WillDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Christine McMahonDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461.
Kira GritsmanDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Jaroslaw P MaciejewskiDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland, OH 44195.
Richard N KitsisDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Ulrich SteidlDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461 ulrich.steidl@einstein.yu.edu.ORCID 0000-0002-9458-1795
Albert Einstein College of Medicine · USCleveland Clinic · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
PI3K Isoform Dependence in Adult Hematopoiesis and Myeloid LeukemiaR01CA196973 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GRITSMAN, KIRA · 2016 to 2020
$2.0M
Role of a Novel Homeobox Transcription Factor (HLX) in Acute Myeloid LeukemiaR01CA166429 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STEIDL, ULRICH · 2013 to 2017
$1.9M
Investigating the role of ARC in hematopoiesis and myeloproliferative neoplasmsF30HL122085 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STANLEY, ROBERT · 2014 to 2015
$96k
NCI NIH HHS P30 CA013330NCI NIH HHS R01 CA166429NCI NIH HHS R01 CA196973NHLBI NIH HHS F30 HL122085NIGMS NIH HHS T32 GM007288NIGMS NIH HHS T32 GM007491
6 · The paper itself

Abstract

Despite the identification of several oncogenic driver mutations leading to constitutive JAK-STAT activation, the cellular and molecular biology of myeloproliferative neoplasms (MPN) remains incompletely understood. Recent discoveries have identified underlying disease-modifying molecular aberrations contributing to disease initiation and progression. Here, we report that deletion of

Indexed as

AnimalsApoptosis Regulatory ProteinsCell Line, TumorHematopoiesis, ExtramedullaryHumansJanus KinasesMiceMice, Inbred C57BLMuscle ProteinsPrimary MyelofibrosisSignal TransductionSTAT3 Transcription FactorTumor Suppressor ProteinsApoptosis Regulatory ProteinsJanus KinasesMuscle ProteinsNOL3 protein, humanNol3 protein, mouseSTAT3 Transcription FactorTumor Suppressor Proteins

Identifiers

PMID28232469
PMCPMC5339683
OpenAlexW2589158219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.