Evidence map›Paper›PMID 28232466›Full record

ArticleBMJ open2017

Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session.

Thomas M Dantoft, Sine Skovbjerg, Linus Andersson, Anna-Sara Claeson, Kaare Engkilde, Nina Lind, Steven Nordin, Lars I Hellgren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).International journal of environmental research and public health · 2021
    Pooled it
  2. Pooled it
  3. Article
  4. Multiple Chemical Sensitivity.Brain sciences · 2021
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Thomas M DantoftDanish Research Centre for Chemical Sensitivities, Copenhagen University Hospital, Gentofte, Denmark.
Sine SkovbjergResearch Centre for Prevention and Health, Copenhagen, Denmark.
Linus AnderssonDepartment of Psychology, Umeå University, Umeå, Sweden.
Anna-Sara ClaesonDepartment of Psychology, Umeå University, Umeå, Sweden.
Kaare EngkildeDepartment of Dermato-Allergology, The National Allergy Research Center, Copenhagen University Hospital Gentofte, Denmark.
Nina LindDepartment of Psychology, Umeå University, Umeå, Sweden.
Steven NordinDepartment of Psychology, Umeå University, Umeå, Sweden.
Lars I HellgrenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Umeå University · SETechnical University of Denmark · DKGentofte Hospital · DKSwedish University of Agricultural Sciences · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the pathophysiological pathways leading to symptoms elicitation in multiple chemical sensitivity (MCS) by comparing gene expression in MCS participants and healthy controls before and after a chemical exposure optimised to cause symptoms among MCS participants.The first hypothesis was that unexposed and symptom-free MCS participants have similar gene expression patterns to controls and a second hypothesis that MCS participants can be separated from controls based on differential gene expression upon a controlled n-butanol exposure.

designParticipants were exposed to 3.7 ppm n-butanol while seated in a windowed exposure chamber for 60 min. A total of 26 genes involved in biochemical pathways found in the literature have been proposed to play a role in the pathogenesis of MCS and other functional somatic syndromes were selected. Expression levels were compared between MCS and controls before, within 15 min after being exposed to and 4 hours after the exposure. SETTINGS: Participants suffering from MCS and healthy controls were recruited through advertisement at public places and in a local newspaper.

participants36 participants who considered themselves sensitive were prescreened for eligibility. 18 sensitive persons fulfilling the criteria for MCS were enrolled together with 18 healthy controls. OUTCOME MEASURES: 17 genes showed sufficient transcriptional level for analysis. Group comparisons were conducted for each gene at the 3 times points and for the computed area under the curve (AUC) expression levels.

resultsMCS participants and controls displayed similar gene expression levels both at baseline and after the exposure and the computed AUC values were likewise comparable between the 2 groups. The intragroup variation in expression levels among MCS participants was noticeably greater than the controls.

conclusionsMCS participants and controls have similar gene expression levels at baseline and it was not possible to separate MCS participants from controls based on gene expression measured after the exposure.

Indexed as

Gene Expression Profiling1-ButanolAdultArea Under CurveCase-Control StudiesDenmarkFemaleHumansInhalation ExposureMaleMiddle AgedMultiple Chemical Sensitivity1-ButanolChemical exposureExposure chamberGene expressionMultiple Chemical SensitivityqPCR

Identifiers

PMID28232466
PMCPMC5337747
OpenAlexW2590518093

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.