ReviewCurrent opinion in genetics & development2017
Intrinsic mechanisms for axon regeneration: insights from injured axons in Drosophila.
Review in Current opinion in genetics & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Neuron-intrinsic and glial pathways regulate sensory cilia regeneration in adultbioRxiv : the preprint server for biology · 2026Article
- An optogenetic assay of Drosophila larval motor neuron performance in vivo.Journal of neuroscience methods · 2026Article
- Study of Axonal Injury and Degeneration inCold Spring Harbor protocols · 2025Article
- Calcium plays an essential role in early-stage dendrite injury detection and regeneration.Progress in neurobiology · 2024Article
- Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration.PLoS genetics · 2024Article
- Rehabilitation of Peripheral Neuropathies: From Lexical Analysis of the Literature to Identification of Clinical Protocols.Journal of clinical medicine · 2023Review
- Ciliated sensory neurons can regenerate axons after complete axon removal.The Journal of experimental biology · 2023Article
- Dendrite regeneration mediates functional recovery after complete dendrite removal.Developmental biology · 2023Article
- Insights into nervous system repair from the fruit fly.Neuronal signaling · 2022Review
- Review
- Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain.Journal of visualized experiments : JoVE · 2021Article
- The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation.Nature communications · 2021Article
- Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling.Nature communications · 2020Article
- Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Pericytes Act as Key Players in Spinal Cord Injury.The American journal of pathology · 2019Review
- An axonal stress response pathway: degenerative and regenerative signaling by DLK.Current opinion in neurobiology · 2018Review
- Intrinsic mechanisms of neuronal axon regeneration.Nature reviews. Neuroscience · 2018Review
- A Drosophila In Vivo Injury Model for Studying Neuroregeneration in the Peripheral and Central Nervous System.Journal of visualized experiments : JoVE · 2018Article
- Discordant Responses to MAPK Pathway Stimulation Include Axonal Growths in AdultFrontiers in molecular neuroscience · 2018Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Axonal damage and loss are common and negative consequences of neuronal injuries, and also occur in some neurodegenerative diseases. For neurons to have a chance to repair their connections, they need to survive the damage, initiate new axonal growth, and ultimately establish new synaptic connections. This review discusses how recent work in Drosophila models have informed our understanding of the cellular pathways used by neurons to respond to axonal injuries. Similarly to mammalian neurons, Drosophila neurons appear to be more limited in their capacity regrow (regenerate) damaged axons in the central nervous system, but can undergo axonal regeneration to varying extents in the peripheral nervous system. Conserved cellular pathways are activated by axonal injury via mechanisms that are specific to axons but not dendrites, and new unanticipated inhibitors of axon regeneration can be identified via genetic screening. These findings, made predominantly via genetic and live imaging methods in Drosophila, emphasize the utility of this model organism for the identification and study of basic cellular mechanisms used for neuronal repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.