Evidence map›Paper›PMID 28232180›Full record

ArticleNeuropharmacology2017

Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons.

Yuan Guo, Zhiyong Zhang, Hsiang-En Wu, Z David Luo, Quinn H Hogan, Bin Pan

Abstract read
In one paragraph

Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Updates in the Treatment of Rosacea with γ-Aminobutyric Acid Derivatives.Clinical, cosmetic and investigational dermatology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. The 5-HTFrontiers in neuroscience · 2020
    Article
  9. Article
  10. Review
  11. Thrombospondins: A Role in Cardiovascular Disease.International journal of molecular sciences · 2017
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuan GuoDepartment of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States.
Zhiyong ZhangDepartment of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States.
Hsiang-En WuDepartment of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States.
Z David LuoDepartment of Anesthesiology & Perioperative Care, University of California Irvine, Irvine, CA 92697, United States; Department of Pharmacology, University of California Irvine, Irvine, CA 92697, United States.
Quinn H HoganDepartment of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States.
Bin PanDepartment of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States. Electronic address: bpan@mcw.edu.
Medical College of Wisconsin · USUniversity of California, Irvine · US

Funding

A novel pathway mediating the development of chronic orofacial neuropathic painR01DE021847 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI LUO, ZHIGANG DAVID, STEWARD, OSWALD · 2011 to 2015
$3.6M
NIDCR NIH HHS R01 DE021847
6 · The paper itself

Abstract

Painful nerve injury disrupts Ca

Indexed as

AnimalsCalciumCalcium ChannelsCalcium SignalingCytoplasmDisease Models, AnimalEndoplasmic ReticulumFemaleGanglia, SpinalMaleMembrane PotentialsMice, 129 StrainMice, KnockoutNeuralgiaPlasma Membrane Calcium-Transporting ATPasesProtein Kinase CCalciumCalcium ChannelsPlasma Membrane Calcium-Transporting ATPasesProtein Kinase CSarcoplasmic Reticulum Calcium-Transporting ATPasesthrombospondin 4ThrombospondinsCa(2+) stores and stimulates store-operated Ca(2+) entryIntracellular calcium signalingNeuropathic painPlasma membrane Ca(2+)-ATPaseSarco-endoplasmic reticulum Ca(2+)-ATPaseThrombospondin-4

Identifiers

PMID28232180
PMCPMC5414309
OpenAlexW2589673763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.