ArticleThe Journal of allergy and clinical immunology2017
Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis.
Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Beyond the Brain: GABAergic Signaling as a Peripheral Modulator of Skin Barrier Immunity.International journal of molecular sciences · 2026Review
- A Conceptual Review of Gut, Skin, and Oral Microbiota in Autoimmune Bullous Diseases: From Dysbiosis to Therapeutic Potential.Journal of inflammation research · 2025Review
- Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis.Nutrients · 2024Review
- Signal detection of adverse events associated with gabapentinoid use for chronic pain.Pharmacoepidemiology and drug safety · 2024Article
- Fc Epsilon RI-Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients.International journal of molecular sciences · 2023Review
- The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility.Frontiers in immunology · 2023Article
- NLRP3 priming due to skin damage precedes LTP allergic sensitization in a mouse model.Scientific reports · 2022Article
- Changes in Gut Microbiota of Patients with Atopic Dermatitis During Balneotherapy.Clinical, cosmetic and investigational dermatology · 2022Article
- Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Peripheral Mechanisms of Neuropathic Pain-the Role of Neuronal and Non-Neuronal Interactions and Their Implications for Topical Treatment of Neuropathic Pain.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Physiology and Pathophysiology of Itch.Physiological reviews · 2020Review
- Neuroimmune interactions in chronic itch of atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2020Review
- Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord.Scientific reports · 2019Article
- Article
- Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model.Scientific reports · 2019Article
- Effects of pruritogens and algogens on rostral ventromedial medullary ON and OFF cells.Journal of neurophysiology · 2018Article
- Opposing effects of cervical spinal cold block on spinal itch and pain transmission.Itch (Philadelphia, Pa.) · 2018Article
- Circuit dissection of the role of somatostatin in itch and pain.Nature neuroscience · 2018Article
- [Neurophysiology of atopic pruritus].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Review
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8 authors at 3 institutions in 4 countries.
Funding
Abstract
backgroundDespite recent insights into the pathophysiology of acute and chronic itch, chronic itch remains an often intractable condition. Among major contributors to chronic itch is dysfunction of spinal cord gamma aminobutyric acidergic (GABAergic) inhibitory controls.
objectivesWe sought to test the hypothesis that selective GABA agonists as well as cell transplant-derived GABA are antipruritic against acute itch and in a transgenic mouse model of atopic dermatitis produced by overexpression of the T
methodsWe injected wild-type and IL-31Tg mice with combinations of GABA-A (muscimol) or GABA-B (baclofen) receptor agonists 15 to 20 minutes prior to injection of various pruritogens (histamine, chloroquine, or endothelin-1) and recorded spontaneous scratching before and after drug administration. We also tested the antipruritic properties of intraspinal transplantation of precursors of GABAergic interneurons in the IL-31Tg mice.
resultsSystemic muscimol or baclofen are antipruritic against both histamine-dependent and -independent pruritogens, but the therapeutic window using either ligand alone was very small. In contrast, combined subthreshold doses of baclofen and muscimol produced a significant synergistic antipruritic effect, with no sedation. Finally, transplant-mediated long-term enhancement of GABAergic signaling not only reduced spontaneous scratching in the IL-31Tg mice but also dramatically resolved the associated skin lesions.
conclusionsAlthough additional research is clearly needed, existing approved GABA agonists should be considered in the management of chronic itch, notably atopic dermatitis.
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