Evidence map›Paper›PMID 28231950›Full record

Trial reportJournal of the American College of Cardiology2017

Myocardial Recovery in Patients With Systolic Heart Failure and Autoantibodies Against β

Yuji Nagatomo, Dennis M McNamara, Jeffrey D Alexis, Leslie T Cooper, G William Dec, Daniel F Pauly, Richard Sheppard, Randall C Starling, W H Wilson Tang, IMAC-2 Investigators

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. βJournal of cardiovascular development and disease · 2023
    Review
  7. Article
  8. Influence of βClinical Medicine Insights. Cardiology · 2022
    Article
  9. Biased activation of βCell death discovery · 2021
    Article
  10. Article
  11. Diagnostic and prognostic value of autoantibodies against βExperimental and therapeutic medicine · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Immune Modulation in Heart Failure: the Promise of Novel Biologics.Current treatment options in cardiovascular medicine · 2018
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yuji NagatomoHeart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio; Sakakibara Heart Institute, Fuchu, Japan.
Dennis M McNamaraHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Jeffrey D AlexisUniversity of Rochester Medical Center School of Medicine and Dentistry, Rochester, New York.
Leslie T CooperMayo Clinic Florida, Jacksonville, Florida.
G William DecMassachusetts General Hospital, Boston, Massachusetts.
Daniel F PaulyTruman Medical Centers, University of Missouri-Kansas City, Kansas City, Missouri.
Richard SheppardJewish General Hospital, Montreal, Quebec, Canada.
Randall C StarlingHeart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio.
W H Wilson TangHeart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address: tangw@ccf.org.
IMAC-2 Investigators

Funding

Identifying and Facilitating Ventricular Recovery on Mechanical SupportR01HL086918 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GORCSAN, JOHN · 2007 to 2011
$3.8M
Nitrative stress in heart failureR01HL103931 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI TANG, WAI HONG WILSON · 2010 to 2014
$3.8M
Genetic Modulation of Left Ventricular RecoveryR01HL075038 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCNAMARA, DENNIS M. · 2004 to 2008
$1.8M
Racial Genomic Differences and Heart Failure OutcomesK24HL069912 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCNAMARA, DENNIS M. · 2002 to 2013
$1.4M
NHLBI NIH HHS K24 HL069912NHLBI NIH HHS R01 HL075038NHLBI NIH HHS R01 HL086918NHLBI NIH HHS R01 HL103931
6 · The paper itself

Abstract

backgroundAmong various cardiac autoantibodies (AAbs), those recognizing the β

objectivesThe goal of this study was to investigate the role of β

methodsPeripheral blood samples were drawn at enrollment in patients with recent-onset cardiomyopathy (left ventricular ejection fraction [LVEF] ≤0.40; <6 months). The presence of IgG and IgG3-β

resultsAmong the 353 patients who had blood samples adequate for the analysis, 62 (18%) were positive for IgG3-β

conclusionsIgG3-β

Indexed as

Adrenergic beta-AntagonistsAdultAutoantibodiesFemaleFollow-Up StudiesHeart Failure, SystolicHumansImmunoglobulin GMaleMiddle AgedProspective StudiesReceptors, Adrenergic, beta-1Recovery of FunctionTreatment OutcomeVentricular Function, LeftAdrenergic beta-AntagonistsAutoantibodiesImmunoglobulin GReceptors, Adrenergic, beta-1autoantibodyIgG3recent-onset cardiomyopathyβ-blocker

Identifiers

PMID28231950
PMCPMC5330212

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.