ArticleBMC neurology2017
Anxiety, emotional processing and depression in people with multiple sclerosis.
Article in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- The prevalence and risk factors of anxiety in multiple sclerosis: A systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Psychiatric comorbidities in multiple sclerosis patients and their relationship with clinical variables: A university hospital sample.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2026Article
- Exploring the relationship between temperament traits, psychological symptoms, and functional disability assessed with the WHODAS 2.0 in persons with multiple sclerosis.Frontiers in neurology · 2025Article
- Alexithymia in multiple sclerosis: past, present and future.Frontiers in human neuroscience · 2025Review
- Unveiling the Psychological Consequences of Illness Perception in Pediatric Multiple Sclerosis: A Parent-Child Study.Children (Basel, Switzerland) · 2024Article
- Mood Associated With Health- and Social Care-Related Quality of Life in Patients With Advanced Multiple Sclerosis.International journal of MS care · 2024Article
- Stressful life events and depression and fatigue in people with multiple sclerosis: a cross-sectional analysis of an international cohort.Acta neurologica Belgica · 2024Article
- Mediation role of anxiety on social support and depression among diabetic patients in elderly caring social organizations in China during COVID-19 pandemic: a cross-sectional study.BMC geriatrics · 2023Article
- The satisfaction of elderly people with elderly caring social organizations and its relationship with social support and anxiety during the COVID-19 pandemic: a cross-sectional study.BMC public health · 2023Article
- Article
- Psychometric properties of the emotional processing scale in individuals with psychiatric symptoms and the development of a brief 15-item version.Scientific reports · 2022Article
- Anxiety and Depression in a Non-Clinical Sample of Young Polish Adults: Presence of Meaning in Life as a Mediator.International journal of environmental research and public health · 2022Article
- Development and validation of the disease - specific problems questionnaire for patients with multiple sclerosis.BMC neurology · 2021Article
- The contribution of self-disclosure to the prediction of mood symptoms in patients with multiple sclerosis.Current journal of neurology · 2021Article
- Anxiety and depression in school-age patients with spinal muscular atrophy: a cross-sectional study.Orphanet journal of rare diseases · 2021Article
- The Impact of Epigallocatechin Gallate and Coconut Oil Treatment on Cortisol Activity and Depression in Multiple Sclerosis Patients.Life (Basel, Switzerland) · 2021Article
- Institutional Satisfaction and Anxiety Mediate the Relationship Between Social Support and Depression in Hypertension Patients in Elderly Caring Social Organizations: A Cross-Sectional Study.Frontiers in psychology · 2021Article
- Depression Comorbid With Stroke, Traumatic Brain Injury, Parkinson's Disease, and Multiple Sclerosis: Diagnosis and Treatment.Focus (American Psychiatric Publishing) · 2020Article
- Toward Further Understanding of Crohn's Disease-Related Fatigue: The Role of Depression and Emotional Processing.Frontiers in psychology · 2020Article
- Effects of enhanced environment and induced depression on cuprizone mouse model of demyelination.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the high comorbidity of anxiety and depression in people with multiple sclerosis (MS), little is known about their inter-relationships. Both involve emotional perturbations and the way in which emotions are processed is likely central to both. The aim of the current study was to explore relationships between the domains of mood, emotional processing and coping and to analyse how anxiety affects coping, emotional processing, emotional balance and depression in people with MS.
methodsA cross-sectional questionnaire study involving 189 people with MS with a confirmed diagnosis of MS recruited from three French hospitals. Study participants completed a battery of questionnaires encompassing the following domains: i. anxiety and depression (Hospital Anxiety and Depression Scale (HADS)); ii. emotional processing (Emotional Processing Scale (EPS-25)); iii. positive and negative emotions (Positive and Negative Emotionality Scale (EPN-31)); iv. alexithymia (Bermond-Vorst Alexithymia Questionnaire) and v. coping (Coping with Health Injuries and Problems-Neuro (CHIP-Neuro) questionnaire. Relationships between these domains were explored using path analysis.
resultsAnxiety was a strong predictor of depression, in both a direct and indirect way, and our model explained 48% of the variance of depression. Gender and functional status (measured by the Expanded Disability Status Scale) played a modest role. Non-depressed people with MS reported high levels of negative emotions and low levels of positive emotions. Anxiety also had an indirect impact on depression via one of the subscales of the Emotional Processing Scale ("Unregulated Emotion") and via negative emotions (EPN-31).
conclusionsThis research confirms that anxiety is a vulnerability factor for depression via both direct and indirect pathways. Anxiety symptoms should therefore be assessed systematically and treated in order to lessen the likelihood of depression symptoms.
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