Evidence map›Paper›PMID 28231807›Full record

ArticleNutrition journal2017

Comparison of direct measures of adiposity with indirect measures for assessing cardiometabolic risk factors in preadolescent girls.

Megan Hetherington-Rauth, Jennifer W Bea, Vinson R Lee, Robert M Blew, Janet Funk, Timothy G Lohman, Scott B Going

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrition journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02654262 (Obesity and Bone Development in Young Girls), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02654262 completednot on this map

Obesity and Bone Development in Young Girls

TypeobservationalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2013 to 2018Enrolled358ConditionsBone Development
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

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  10. Physical activity, sedentary time, and longitudinal bone strength in adolescent girls.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Article
  11. Article
  12. Revisiting the Global Overfat Pandemic.Frontiers in public health · 2020
    Article
  13. Article
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  15. Relationship between fat distribution and cardiometabolic risk in Hispanic girls.American journal of human biology : the official journal of the Human Biology Council · 2018
    Article
  16. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Megan Hetherington-RauthDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721, USA. mchr@email.arizona.edu.ORCID 0000-0003-1825-8010
Jennifer W BeaDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721, USA.
Vinson R LeeDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721, USA.
Robert M BlewDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721, USA.
Janet FunkDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721, USA.
Timothy G LohmanDepartment of Physiology, University of Arizona, Tucson, AZ, 85721, USA.
Scott B GoingDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721, USA.
University of Arizona · US

Funding

Obesity and bone development in young girlsR01HD074565 · NICHD · UNIVERSITY OF ARIZONA · PI GOING, SCOTT B · 2013 to 2017
$2.6M
NICHD NIH HHS R01 HD074565
6 · The paper itself

Abstract

backgroundChildhood overweight and obesity remains high, contributing to cardiometabolic risk factors at younger ages. It is unclear which measures of adiposity serve as the best proxies for identifying children at metabolic risk. This study assessed whether DXA-derived direct measures of adiposity are more strongly related to cardiometabolic risk factors in children than indirect measures.

methodsAnthropometric and DXA measures of adiposity and a comprehensive assessment of cardiometabolic risk factors were obtained in 288, 9-12 year old girls, most being of Hispanic ethnicity. Multiple regression models for each metabolic parameter were run against each adiposity measure while controlling for maturation and ethnicity. In addition, regression models including both indirect and direct measures were developed to assess whether using direct measures of adiposity could provide a better prediction of the cardiometabolic risk factors beyond that of using indirect measures alone.

resultsMeasures of adiposity were significantly correlated with cardiometabolic risk factors (p < 0.05) except fasting glucose. After adjusting for maturation and ethnicity, indirect measures of adiposity accounted for 29-34% in HOMA-IR, 10-13% in TG, 14-17% in HDL-C, and 5-8% in LDL-C while direct measures accounted for 29-34% in HOMA-IR, 10-12% in TG, 13-16% in HDL-C, and 5-6% in LDL-C. The addition of direct measures of adiposity to indirect measures added significantly to the variance explained for HOMA-IR (p = 0.04).

conclusionAnthropometric measures may perform as well as the more precise direct DXA-derived measures of adiposity for assessing most CVD risk factors in preadolescent girls. The use of DXA-derived adiposity measures together with indirect measures may be advantageous for predicting insulin resistance risk.

trial registrationNCT02654262 . Retrospectively registered 11 January 2016.

Indexed as

AdiposityAbsorptiometry, PhotonBlood GlucoseBody CompositionBody Mass IndexCardiovascular DiseasesChildCholesterol, HDLCholesterol, LDLC-Reactive ProteinCross-Sectional StudiesFemaleHumansLinear ModelsMetabolic SyndromeObesityBlood GlucoseCholesterol, HDLCholesterol, LDLC-Reactive ProteinTriglyceridesBody compositionCardiovascular diseaseGirls

Identifiers

PMID28231807
PMCPMC5324258
OpenAlexW2590694363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.