ArticleThe American journal of psychiatry2017
Association of Elevated Reward Prediction Error Response With Weight Gain in Adolescent Anorexia Nervosa.
Article in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Moving towards specificity: A systematic review of cue features associated with reward and punishment in anorexia nervosa.Clinical psychology review · 2020Pooled it
- Ketone Supplementation Attenuates Prediction Error Taste Response in Eating Disorders: A Proof-of-Concept Study.The International journal of eating disorders · 2026Trial
- A pontomesencephalic-mesolimbic circuit modulates activity-based anorexia.Science advances · 2026Article
- A neurodevelopmental model of eating disorder risk in midlife to older adulthood.Neuroscience and biobehavioral reviews · 2026Review
- Modeling metacognition and executive functions in the metacognitive wisconsin card sorting test using the neuropsychological digital-twin method.Scientific reports · 2026Article
- Striatal and hippocampal contributions to value-based learning in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Evidence of Altered Biobehavioral Threat Processes in Adolescents With Eating Disorders: A Scoping Review.The International journal of eating disorders · 2025Article
- Exploring Habits in Anorexia Nervosa: Promise, Pitfalls, and Progress.Current psychiatry reports · 2025Review
- Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Computational Perspectives on Cognition in Anorexia Nervosa: A Systematic Review.Computational psychiatry (Cambridge, Mass.) · 2025Review
- Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025Review
- The adamant adherence to a prior belief: the case of anosognosia in anorexia nervosa.Frontiers in neurology · 2025Article
- Predictors of treatment outcome in higher levels of care among a large sample of adolescents with heterogeneous eating disorders.Child and adolescent psychiatry and mental health · 2024Article
- Weight gained during treatment predicts 6-month body mass index in a large sample of patients with anorexia nervosa using ensemble machine learning.The International journal of eating disorders · 2024Article
- Altered learning from positive feedback in adolescents with anorexia nervosa.Journal of the International Neuropsychological Society : JINS · 2024Article
- Testing the role of associative learning in evidence-based treatments for anorexia nervosa.The International journal of eating disorders · 2024Review
- Neural Response to Expecting a Caloric Sweet Taste Stimulus Predicts Body Mass Index Longitudinally Among Young Adult Women With Anorexia Nervosa.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Therapeutic ketogenic diet as treatment for anorexia nervosa.Frontiers in nutrition · 2024Review
- Brain, behavior, cognition, and physical health in first-onset adolescent anorexia nervosa: The BRAVE Study design and cohort profile.Aperture neuro · 2024Article
- Back to the future: Progressing memory research in eating disorders.The International journal of eating disorders · 2023Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAnorexia nervosa is a psychiatric disorder of unknown etiology. Understanding associations between behavior and neurobiology is important in treatment development. Using a novel monetary reward task during functional magnetic resonance brain imaging, the authors tested how brain reward learning in adolescent anorexia nervosa changes with weight restoration.
methodFemale adolescents with anorexia nervosa (N=21; mean age, 16.4 years [SD=1.9]) underwent functional MRI (fMRI) before and after treatment; similarly, healthy female control adolescents (N=21; mean age, 15.2 years [SD=2.4]) underwent fMRI on two occasions. Brain function was tested using the reward prediction error construct, a computational model for reward receipt and omission related to motivation and neural dopamine responsiveness.
resultsCompared with the control group, the anorexia nervosa group exhibited greater brain response 1) for prediction error regression within the caudate, ventral caudate/nucleus accumbens, and anterior and posterior insula, 2) to unexpected reward receipt in the anterior and posterior insula, and 3) to unexpected reward omission in the caudate body. Prediction error and unexpected reward omission response tended to normalize with treatment, while unexpected reward receipt response remained significantly elevated. Greater caudate prediction error response when underweight was associated with lower weight gain during treatment. Punishment sensitivity correlated positively with ventral caudate prediction error response.
conclusionsReward system responsiveness is elevated in adolescent anorexia nervosa when underweight and after weight restoration. Heightened prediction error activity in brain reward regions may represent a phenotype of adolescent anorexia nervosa that does not respond well to treatment. Prediction error response could be a neurobiological marker of illness severity that can indicate individual treatment needs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.