Trial reportThe Journal of physiology2017
Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase.
Trial report in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Preworkout dietary nitrate magnifies training-induced benefits to physical function in late postmenopausal women: a randomized pilot study.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Trial
- Estrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.Journal of menopausal medicine · 2026Review
- Arteries and Hearts in Motion: Sex Differences in Exercise-Mediated Protection Against Atherosclerotic Cardiovascular Disease Risk.Current atherosclerosis reports · 2025Review
- Unveiling the role of exercise in modulating plasma heat shock protein 27 levels: insights for exercise immunology and cardiovascular health.Molecular and cellular biochemistry · 2025Review
- Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus.Nature reviews. Endocrinology · 2025Review
- Higher amounts of habitual physical activity changes the relationship between hot flashes and subclinical cardiovascular disease risk.Physiological reports · 2025Article
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35/NFκB p65 pathway.Journal of orthopaedic translation · 2022Article
- Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Review
- Short-Term Supplementation With Fermented Red Clover Extract Reduces Vascular Inflammation in Early Post-menopausal Women.Frontiers in cardiovascular medicine · 2022Article
- Physiological Responses to Low-Volume Interval Training in Women.Sports medicine - open · 2021Review
- Aerobic High-Intensity Exercise Training Improves Cardiovascular Health in Older Post-menopausal Women.Frontiers in aging · 2021Article
- Does Exercise Influence the Susceptibility to Arterial Thrombosis? An Integrative Perspective.Frontiers in physiology · 2021Review
- The effect of lifelong endurance exercise on cardiovascular structure and exercise function in women.The Journal of physiology · 2020Article
- Increased prostacyclin formation after high-intensity interval training in late postmenopausal women.European journal of applied physiology · 2020Article
- The Protective Role of Regular Aerobic Exercise on Vascular Function with Aging.Current opinion in physiology · 2019Article
- The Role of Physical Activity Prescription in Cardiovascular Disease Prevention Amongst South Asian Canadians.Frontiers in cardiovascular medicine · 2018Review
- Exercise and oestrogens: aerobic high-intensity exercise promotes leg vascular and skeletal muscle mitochondrial adaptations in early postmenopause.The Journal of physiology · 2017Article
- Found in 'transition': shifting mechanisms of aerobic exercise adaptation in ageing women.The Journal of physiology · 2017Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsExercise training effectively improves vascular and skeletal muscle function; however, these effects of training may be blunted in postmenopausal women as a result of the loss of oestrogens. Accordingly, the capacity to deliver oxygen to the active muscles may also be impaired in postmenopausal women. In both premenopausal and recent postmenopausal women, exercise training was shown to improve leg vascular and skeletal muscle mitochondrial function. Interestingly, these effects were more pronounced in postmenopausal women. Skeletal muscle oxygen supply and utilization were similar in the two groups of women. These findings suggest that the early postmenopausal phase is associated with an enhanced capacity of the leg vasculature and skeletal muscle mitochondria to adapt to exercise training and that the ability to deliver oxygen to match the demand of the active muscles is preserved in the early phase following the menopausal transition. ABSTRACT: Exercise training leads to favourable adaptations within skeletal muscle; however, this effect of exercise training may be blunted in postmenopausal women as a result of the loss of oestrogens. Furthermore, postmenopausal women may have an impaired vascular response to acute exercise. We examined the haemodynamic response to acute exercise in matched pre- and postmenopausal women before and after 12 weeks of aerobic high intensity exercise training. Twenty premenopausal and 16 early postmenopausal (mean ± SEM: 3.1 ± 0.5 years after final menstrual period) women only separated by 4 years of age (mean ± SEM: 50 ± 0 years vs. 54 ± 1 years) were included. Before training, leg blood flow, O
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.