Evidence map›Paper›PMID 28231567›Full record

ReviewJournal of innate immunity2017

Innate Lung Defense during Invasive Aspergillosis: New Mechanisms.

Jaleesa M Garth, Chad Steele

Open access · goldAbstract readReview
In one paragraph

Review in Journal of innate immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The Pathogenesis ofPolish journal of microbiology · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Antifungal Drugs Influence Neutrophil Effector Functions.Antimicrobial agents and chemotherapy · 2019
    Article
  11. Article
  12. Pattern recognition receptors in fungal immunity.Seminars in cell & developmental biology · 2019
    Review
  13. Review
  14. Role of theFrontiers in microbiology · 2019
    Article
  15. Full Complement.Journal of innate immunity · 2018
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jaleesa M GarthDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Chad Steele
University of Alabama at Birmingham · US

Funding

Immunopathogenesis in fungal asthmaR01HL122426 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Chad Steele · 2015 to 2026
$5.1M
Biology of innate IL-22 during lung fungal infectionR01HL136211 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEELE, CHAD · 2017 to 2024
$3.0M
NHLBI NIH HHS R01 HL122426NHLBI NIH HHS R01 HL136211
6 · The paper itself

Abstract

Invasive aspergillosis (IA) is one of the most difficult to treat and, consequently, one of the most lethal fungal infections known to man. Continued use of immunosuppressive agents during chemotherapy and organ transplantation often leads to the development of neutropenia, the primary risk factor for IA. However, IA is also becoming more appreciated in chronic diseases associated with corticosteroid therapy. The innate immune response to Aspergillus fumigatus, the primary agent in IA, plays a pivotal role in the recognition and elimination of organisms from the pulmonary system. This review highlights recent findings about innate host defense mechanisms, including novel aspects of innate cellular immunity and pathogen recognition, and the inflammatory mediators that control infection with A. fumigatus.

Indexed as

AnimalsAntifungal AgentsAspergillosisAspergillus fumigatusCytokinesHumansImmunity, InnateInflammation MediatorsLungReceptors, Pattern RecognitionAntifungal AgentsCytokinesInflammation MediatorsReceptors, Pattern RecognitionAspergillus fumigatusCytokinesInnate immunityPattern recognition receptors

Identifiers

PMID28231567
PMCPMC5475230
OpenAlexW2590092017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.