ArticleNeuron2017
Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Perturbed cell fate decision by schizophrenia-associated AS3MTScience advances · 2025Article
- Hedgehog signaling controls astral microtubules and mitotic spindle orientation in neural progenitors and iPSCs.Frontiers in cell and developmental biology · 2025Article
- GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation.Life science alliance · 2024Article
- Growth/differentiation factor 15 controls ependymal and stem cell number in the V-SVZ.Stem cell reports · 2024Article
- The Symmetry of Neural Stem Cell and Progenitor Divisions in the Vertebrate Brain.Frontiers in cell and developmental biology · 2022Review
- Live-cell imaging of microglial interactions with radial glia in transgenic embryonic mouse brains using slice culture.STAR protocols · 2021Article
- The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus.Cell reports · 2021Article
- Regulation of the Brain Neural Niche by Soluble Molecule Akhirin.Journal of developmental biology · 2021Review
- Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit.Neuron · 2020Article
- Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.Developmental cell · 2020Article
- Neurogenesis From Embryo to Adult - Lessons From Flies and Mice.Frontiers in cell and developmental biology · 2020Review
- Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?Inflammation and regeneration · 2020Review
- Harnessing region-specific neurovascular signaling to promote germinal matrix vessel maturation and hemorrhage prevention.Disease models & mechanisms · 2019Article
- Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.The EMBO journal · 2019Article
- Article
- Article
- Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids.APL bioengineering · 2018Review
- Molecular components and polarity of radial glial cells during cerebral cortex development.Cellular and molecular life sciences : CMLS · 2018Review
- Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells.Genes · 2018Review
- Radial glia in the ventral telencephalon.FEBS letters · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The developmental mechanisms regulating the number of adult neural stem cells (aNSCs) are largely unknown. Here we show that the cleavage plane orientation in murine embryonic radial glia cells (RGCs) regulates the number of aNSCs in the lateral ganglionic eminence (LGE). Randomizing spindle orientation in RGCs by overexpression of Insc or a dominant-negative form of Lgn (dnLgn) reduces the frequency of self-renewing asymmetric divisions while favoring symmetric divisions generating two SNPs. Importantly, these changes during embryonic development result in reduced seeding of aNSCs. Interestingly, no effects on aNSC numbers were observed when Insc was overexpressed in postnatal RGCs or aNSCs. These data suggest a new mechanism for controlling aNSC numbers and show that the role of spindle orientation during brain development is highly time and region dependent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.