ArticlePloS one2017
The pathogens profile in children with otitis media with effusion and adenoid hypertrophy.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 91 citations in OpenAlex.
- Compare two surgical interventions for otitis media with effusion in young children.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Trial
- Trial
- Dysbiosis and Links of the Middle Ear, Nasal, and Oral Microbiota in Chronic Otitis Media with Effusion.MedComm · 2025Article
- [Current hypotheses on the development of chronic otitis media with effusion in childhood].HNO · 2025Review
- The pediatric nasal microbiome and its role in chronic ENT disorders: a narrative review.Frontiers in immunology · 2025Review
- Analyzing the characteristics of Otitis media with effusion following SARS-CoV-2 infection in China.Frontiers in surgery · 2025Article
- Otitis media with effusion in preschool children with adenoid hypertrophy: Risk factors and nursing care.Nursing open · 2024Article
- Allergen Immunotherapy for a Year Can Effectively Reduce the Risk of Postoperative Recurrence of Adenoid Hypertrophy in Children with Concurrent Allergic Rhinitis (IMPROVEII).Journal of asthma and allergy · 2024Article
- Selenadiazole Inhibited Adenovirus-Induced Apoptosis through the Oxidative-Damage-Mediated Bcl-2/Stat 3/NF-κB Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Adenoid Hypertrophy and Orthodontic Complications: An Assessment of Parental Knowledge in Saudi Arabia.Cureus · 2023Article
- Biofilm-Forming Bacteria Implicated in Complex Otitis Media in Children in the Post-Heptavalent Pneumococcal Conjugate Vaccine (PCV7) Era.Microorganisms · 2023Article
- Proteomic Study of Middle Ear Effusion and Its Clinical Application for Otitis Media with Effusion.Infection and drug resistance · 2023Article
- Viral infection in chronic otitis media with effusion in children.Frontiers in pediatrics · 2023Article
- Analysis of factors that influence the occurrence of otitis media with effusion in pediatric patients with adenoid hypertrophy.Frontiers in pediatrics · 2023Article
- Altered intestinal microbiota enhances adenoid hypertrophy by disrupting the immune balance.Frontiers in immunology · 2023Article
- Impact of COVID-19 Pandemic and Pattern of Patient Care in Otorhinolaryngology Practice in a Tertiary Referral Centre.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- An Experience of Otorhinolaryngologists as Frontline Worker with Novel Coronavirus: A Qualitative Analysis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Article
- Risk factors and antibiotic sensitivity of aerobic bacteria in Chinese children with adenoid hypertrophy.BMC pediatrics · 2022Article
- ADENOID SIZE IN CHILDREN WITH OTITIS MEDIA WITH EFFUSION.Acta clinica Croatica · 2022Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the presence of viruses and bacteria in middle ear and adenoids of patients with and without otitis media with effusion (OME).
methodsAdenoid samples and middle ear washes (MEW) were obtained from children with OME associated with adenoid hypertrophy undergoing adenoidectomy and tympanostomy, and compared to those obtained from patients undergoing cochlear implant surgery, as a control group. Specific DNA or RNA of 9 respiratory viruses (rhinovirus, influenza virus, picornavirus, syncytial respiratory virus, metapneumovirus, coronavirus, enterovirus, adenovirus and bocavirus) and 5 bacteria (S. pneumoniae, H. influenzae, M. catarrhalis, P. aeruginosa and S. aureus) were extracted and quantified by real-time PCR.
results37 OME and 14 cochlear implant children were included in the study. At the adenoid, virus and bacteria were similarly detected in both OME and control patients. At the middle ear washes, however, a higher prevalence of bacteria was observed in patients with OME (p = 0.01). S. pneumoniae (p = 0.01) and M. catarrhalis (p = 0.022) were the bacteria responsible for this difference. Although total virus detection was not statistically different from controls at the middle ear washes (p = 0.065), adenovirus was detected in higher proportions in adenoid samples of OME patients than controls (p = 0.019).
conclusionsDespite both OME and control patients presented similar rates of viruses and bacteria at the adenoid, children with OME presented higher prevalence of S. pneumonia, M. catarrhalis in middle ear and adenovirus in adenoids when compared to controls. These findings could suggest that these pathogens could contribute to the fluid persistence in the middle ear.
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