ArticlePloS one2017
Photoacoustic imaging features of intraocular tumors: Retinoblastoma and uveal melanoma.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
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Who cites it
17 citing papers in PubMed.
- Potential of photoacoustic imaging for assessing tumor perfusion in intraocular tumors and high-resolution choroidal microvascular imaging: from technical advances to clinical translation.Frontiers in oncology · 2026Review
- 3D imaging of aqueous veins and surrounding sclera using a dual-wavelength photoacoustic microscopy.Biomedical optics express · 2023Article
- Review
- Article
- Review
- Safety Evaluation of Photoacoustic Tomography System for Intraocular Tumors.Translational vision science & technology · 2022Article
- Label-Free Delineation of Human Uveal Melanoma Infiltration With Pump-Probe Microscopy.Frontiers in oncology · 2022Article
- Method for the biomechanical analysis of aqueous veins and perilimbal sclera by three-dimensional photoacoustic imaging and strain field calculation.Scientific reports · 2021Article
- Characterizing the aggressiveness of prostate cancer using an all-optical needle photoacoustic sensing probe: feasibility study.Biomedical optics express · 2021Article
- Photoacoustic spectral analysis at ultraviolet wavelengths for characterizing the Gleason grades of prostate cancer.Optics letters · 2020Article
- Towards Clinical Translation of LED-Based Photoacoustic Imaging: A Review.Sensors (Basel, Switzerland) · 2020Review
- State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics.Contrast media & molecular imaging · 2019Review
- Light Emitting Diodes based Photoacoustic Imaging and Potential Clinical Applications.Scientific reports · 2018Article
- Interstitial assessment of aggressive prostate cancer by physio-chemical photoacoustics: An ex vivo study with intact human prostates.Medical physics · 2018Article
- Bioinspired Multifunctional Melanin-Based Nanoliposome for Photoacoustic/Magnetic Resonance Imaging-Guided Efficient Photothermal Ablation of Cancer.Theranostics · 2018Article
- Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging.Scientific reports · 2017Article
- Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The purpose of this study is to examine the capability of photoacoustic (PA) imaging (PAI) in assessing the unique molecular and architectural features in ocular tumors. A real-time PA and ultrasonography (US) parallel imaging system based on a research US platform was developed to examine retinoblastoma in mice in vivo and human retinoblastoma and uveal melanoma ex vivo. PA signals were generated by optical illumination at 720, 750, 800, 850, 900 and 950 nm delivered through a fiber optical bundle. The optical absorption spectra of the tumors were derived from the PA images. The optical absorption spectrum of each tumor was quantified by fitting to a polynomial model. The microscopic architectures of the tumors were quantified by frequency domain analysis of the PA signals. Both the optical spectral and architectural features agree with the histological findings of the tumors. The mouse and human retinoblastoma showed comparable total optical absorption spectra at a correlation of 0.95 (p<0.005). The quantitative PAI features of human retinoblastoma and uveal melanoma have shown statistically significant difference in two tailed t-tests (p<0.05). Fully compatible with the concurrent procedures, PAI could be a potential tool complementary to other diagnostic modalities for characterizing intraocular tumors.
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Registered trials
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