Evidence map›Paper›PMID 28231292›Full record

SynthesisPloS one2017

A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis.

Miriam Abraham, Salem Alramadhan, Carmen Iniguez, Liesbeth Duijts, Vincent W V Jaddoe, Herman T Den Dekker, Sarah Crozier, Keith M Godfrey, Peter Hindmarsh, Torstein Vik and 5 more

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07201181 (Association of Prenatal Tobacco Exposure Verified by Maternal Urinary Cotinine With Umbilical Cord Blood Lactate, Fetal Carboxyhemoglobin, and Early Neonatal Outcomes), which is not on this map. Cited by 139 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 14 pooled it
34.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07201181 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Association of Prenatal Tobacco Exposure Verified by Maternal Urinary Cotinine With Umbilical Cord Blood Lactate, Fetal Carboxyhemoglobin, and Early Neonatal Outcomes: A Prospective Single-Center Observational Study

TypeobservationalSponsorHaseki Training and Research HospitalRan2026 to 2027Enrolled126ConditionsTobacco Smoke Pollution, Maternal Exposure During Pregnancy, Infant, Newborn, Carbon Monoxide PoisoningArmsMaternal Urinary Cotinine Assessment
3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 14 syntheses or guidelines pooled it, 286 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Article
  19. Elevated lipoprotein(a) and adverse pregnancy outcomes.Annals of medicine and surgery (2012) · 2026
    Review
  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 5 countries.

Miriam AbrahamChild Health, University of Aberdeen, Aberdeen, United Kingdom.
Salem AlramadhanChild Health, University of Aberdeen, Aberdeen, United Kingdom.
Carmen IniguezFISABIO - Universitat Jaume I - Universitat de València Epidemiology and Environmental Health Joint Research Unit and Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Valencia, Spain.
Liesbeth DuijtsThe Generation R Study, Department of Paediatrics, Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Vincent W V JaddoeThe Generation R Study, Department of Paediatrics, Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Herman T Den DekkerThe Generation R Study, Department of Paediatrics, Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Sarah CrozierMRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
Keith M GodfreyMRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
Peter HindmarshUniversity College London, London, United Kingdom.
Torstein VikFaculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Geir W JacobsenFaculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Wojciech HankeDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Wojciech SobalaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Graham DevereuxChild Health, University of Aberdeen, Aberdeen, United Kingdom.
Steve TurnerChild Health, University of Aberdeen, Aberdeen, United Kingdom.ORCID http://orcid.org/0000-0001-8393-5060
University of Aberdeen · GBErasmus MC · NLNofer Institute of Occupational Medicine · PLNorwegian University of Science and Technology · NOUniversity Hospital Southampton NHS Foundation Trust · GBUniversitat Jaume I · ESUniversity College London · GB

Funding

British Heart Foundation PG/14/33/30827British Heart Foundation RG/15/17/31749Medical Research Council MC_PC_13040Medical Research Council MC_U147574222Medical Research Council MC_U147574226Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/4Medical Research Council MR/K007017/1Medical Research Council MR/M501633/1Medical Research Council MR/M501633/2
6 · The paper itself

Abstract

backgroundMaternal smoking during pregnancy is linked to reduced birth weight but the gestation at onset of this relationship is not certain. We present a systematic review of the literature describing associations between maternal smoking during pregnancy and ultrasound measurements of fetal size, together with an accompanying meta-analysis.

methodsStudies were selected from electronic databases (OVID, EMBASE and Google Scholar) that examined associations between maternal smoking or smoke exposure and antenatal fetal ultrasound measurements. Outcome measures were first, second or third trimester fetal measurements.

resultsThere were 284 abstracts identified, 16 papers were included in the review and the meta-analysis included data from eight populations. Maternal smoking was associated with reduced second trimester head size (mean reduction 0.09 standard deviation (SD) [95% CI 0.01, 0.16]) and femur length (0.06 [0.01, 0.10]) and reduced third trimester head size (0.18 SD [0.13, 0.23]), femur length (0.27 SD [0.21, 0.32]) and estimated fetal weight (0.18 SD [0.11, 0.24]). Higher maternal cigarette consumption was associated with a lower z score for head size in the second (mean difference 0.09 SD [0, 0.19]) and third (0.15 SD [0.03, 0.26]) trimesters compared to lower consumption. Fetal measurements were not reduced for those whose mothers quit before or after becoming pregnant compared to mothers who had never smoked.

conclusionsMaternal smoking during pregnancy is associated with reduced fetal measurements after the first trimester, particularly reduced head size and femur length. These effects may be attenuated if mothers quit or reduce cigarette consumption during pregnancy.

Indexed as

Fetal DevelopmentBirth WeightFemaleFetal Growth RetardationHeadHumansPregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondPregnancy Trimester, ThirdSmokingTobacco Smoke PollutionTobacco Smoke Pollution

Identifiers

PMID28231292
PMCPMC5322900
OpenAlexW2589713358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.