ArticlePLoS genetics2017
Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Hippo signaling regulates cuticle pigmentation and dopamine metabolism in Drosophila.PLoS genetics · 2026Article
- The Enigmas of Tissue Closure: Inspiration fromCurrent issues in molecular biology · 2024Review
- The Tbx6 Transcription Factor Dorsocross Mediates Dpp Signaling to RegulateInternational journal of molecular sciences · 2022Article
- Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using aG3 (Bethesda, Md.) · 2020Article
- Orchestrating morphogenesis: building the body plan by cell shape changes and movements.Development (Cambridge, England) · 2020Review
- Identifying Genetic Players in Cell Sheet Morphogenesis Using aG3 (Bethesda, Md.) · 2018Article
- Wound healing, calcium signaling, and other novel pathways are associated with the formation of butterfly eyespots.BMC genomics · 2017Article
- Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.Annual review of cell and developmental biology · 2017Review
- The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling.PLoS genetics · 2017Article
- Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure.PLoS genetics · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
Tissue morphogenesis relies on proper differentiation of morphogenetic domains, adopting specific cell behaviours. Yet, how signalling pathways interact to determine and coordinate these domains remains poorly understood. Dorsal closure (DC) of the Drosophila embryo represents a powerful model to study epithelial cell sheet sealing. In this process, JNK (JUN N-terminal Kinase) signalling controls leading edge (LE) differentiation generating local forces and cell shape changes essential for DC. The LE represents a key morphogenetic domain in which, in addition to JNK, a number of signalling pathways converges and interacts (anterior/posterior -AP- determination; segmentation genes, such as Wnt/Wingless; TGFβ/Decapentaplegic). To better characterize properties of the LE morphogenetic domain, we sought out new JNK target genes through a genomic approach: 25 were identified of which 8 are specifically expressed in the LE, similarly to decapentaplegic or puckered. Quantitative in situ gene profiling of this new set of LE genes reveals complex patterning of the LE along the AP axis, involving a three-way interplay between the JNK pathway, segmentation and HOX genes. Patterning of the LE into discrete domains appears essential for coordination of tissue sealing dynamics. Loss of anterior or posterior HOX gene function leads to strongly delayed and asymmetric DC, due to incorrect zipping in their respective functional domain. Therefore, in addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing.
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