Evidence map›Paper›PMID 28231043›Full record

ArticleeLife2017

Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.

Silvia Ripamonti, Mateusz C Ambrozkiewicz, Francesca Guzzi, Marta Gravati, Gerardo Biella, Ingo Bormuth, Matthieu Hammer, Liam P Tuffy, Albrecht Sigler, Hiroshi Kawabe and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 86 citations in OpenAlex.

  1. Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Trial
  2. Lasting effects of early-life oxytocin treatment on LTP and episodic memory in a mouse model of Fragile X syndrome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  8. Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Silvia RipamontiDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Mateusz C AmbrozkiewiczDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Francesca GuzziDepartment of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Marta GravatiDepartment of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Gerardo BiellaDepartment of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Ingo BormuthCortical Development, Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin, Berlin, Germany.
Matthieu HammerDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Liam P TuffyDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Albrecht SiglerDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Hiroshi KawabeDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Katsuhiko NishimoriDepartment of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan.
Mauro ToselliDepartment of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Marco ParentiDepartment of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
JeongSeop RheeDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID 0000-0002-8560-3630
Max Planck Institute of Experimental Medicine · DEUniversity of Pavia · ITNeuroscience Institute · ITCharité - Universitätsmedizin Berlin · DETohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beyond its role in parturition and lactation, oxytocin influences higher brain processes that control social behavior of mammals, and perturbed oxytocin signaling has been linked to the pathogenesis of several psychiatric disorders. However, it is still largely unknown how oxytocin exactly regulates neuronal function. We show that early, transient oxytocin exposure

Indexed as

Cell DifferentiationSignal TransductionAnimalsCells, CulturedHippocampusMice, KnockoutNeuronsOxytocinOxytocinautismmouseneurosciencepeptide hormonessynapses

Identifiers

PMID28231043
PMCPMC5323041
OpenAlexW2590592231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.