Evidence map›Paper›PMID 28230909›Full record

ArticleBiometrics2017

A general instrumental variable framework for regression analysis with outcome missing not at random.

Eric J Tchetgen Tchetgen, Kathleen E Wirth

Abstract read
In one paragraph

Article in Biometrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Treating gaps and biases in biodiversity data as a missing data problem.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Causal Inference With Outcome-Dependent Missingness And Self-Censoring.Proceedings of machine learning research · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eric J Tchetgen TchetgenDepartment of Biostatistics, Harvard T.H. Chan School of Public Health 655 Huntington Avenue, Boston, Massachusetts 02115, U.S.A.
Kathleen E WirthDepartment of Epidemiology, Harvard T.H. Chan School of Public Health 677 Huntington Avenue, Boston, Massachusetts 02115, U.S.A.

Funding

Next Generation Missing Data Methods in HIV ResearchR01AI127271 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TCHETGEN TCHETGEN, ERIC JOEL · 2017 to 2021
$3.2M
Identification and Inference for Longitudinal Causal Mediation Analysis in HIVR01AI104459 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHPITSER, ILYA, VANDERWEELE, TYLER · 2013 to 2017
$2.0M
Semiparametric Methods for Gene-environment InteractionR01ES020337 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI TCHETGEN TCHETGEN, ERIC JOEL · 2012 to 2015
$1.4M
NIAID NIH HHS R01 AI104459NIAID NIH HHS R01 AI127271NIEHS NIH HHS R01 ES020337
6 · The paper itself

Abstract

The instrumental variable (IV) design is a well-known approach for unbiased evaluation of causal effects in the presence of unobserved confounding. In this article, we study the IV approach to account for selection bias in regression analysis with outcome missing not at random. In such a setting, a valid IV is a variable which (i) predicts the nonresponse process, and (ii) is independent of the outcome in the underlying population. We show that under the additional assumption (iii) that the IV is independent of the magnitude of selection bias due to nonresponse, the population regression in view is nonparametrically identified. For point estimation under (i)-(iii), we propose a simple complete-case analysis which modifies the regression of primary interest by carefully incorporating the IV to account for selection bias. The approach is developed for the identity, log and logit link functions. For inferences about the marginal mean of a binary outcome assuming (i) and (ii) only, we describe novel and approximately sharp bounds which unlike Robins-Manski bounds, are smooth in model parameters, therefore allowing for a straightforward approach to account for uncertainty due to sampling variability. These bounds provide a more honest account of uncertainty and allows one to assess the extent to which a violation of the key identifying condition (iii) might affect inferences. For illustration, the methods are used to account for selection bias induced by HIV testing nonparticipation in the evaluation of HIV prevalence in the Zambian Demographic and Health Surveys.

Indexed as

Regression AnalysisSelection BiasComputer SimulationHIV InfectionsHumansMass ScreeningModels, StatisticalPatient CompliancePrevalenceUncertaintyZambiaComplete-case analysisInstrumental variableNonignorable missing dataSelection bias

Identifiers

PMID28230909
PMCPMC5569006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.