ArticleThe International journal of eating disorders2017
Estrogenic suppression of binge-like eating elicited by cyclic food restriction and frustrative-nonreward stress in female rats.
Article in The International journal of eating disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Systematic Review of Binge Eating Rodent Models for Developing Novel or Repurposing Existing Pharmacotherapies.Biomolecules · 2023Pooled it
- Combined Oral Contraceptive Use and Binge Eating.JAMA network open · 2026Article
- Advancing translational research in binge-eating: Integrating insights from clinical practice into animal models.Translational psychiatry · 2026Review
- Influence of caloric restriction history, intermittent exposure to palatable food and sex in a binge eating model in C57BL/6J mice.Journal of eating disorders · 2025Article
- Within-Person Changes in Daily Ovarian Hormone Levels Influence Genetic Effects on Emotional Eating in Women.The International journal of eating disorders · 2025Article
- Gondal hormones and binge eating in females: developmental and etiologic insights from puberty to adulthood.Current opinion in psychiatry · 2025Review
- Novel rat model of gaming disorder: assessment of social reward and sex differences in behavior and c-Fos brain activity.Psychopharmacology · 2025Article
- Review
- The role of motivation in eating disorders: understanding sex differences in the circuits.Frontiers in behavioral neuroscience · 2025Review
- Sucrose binge-eating and increased anxiety-like behavior in Sprague-Dawley rats exposed to repeated LPS administration followed by chronic mild unpredictable stress.Scientific reports · 2024Article
- Ovarian Hormones and Binge Eating in Adulthood: Summary of Findings and Implications for Individual Differences in Risk in Women.Current directions in psychological science · 2023Article
- The organizational role of ovarian hormones during puberty on risk for binge-like eating in rats.Physiology & behavior · 2023Review
- Neurodevelopmental Model Explaining Associations between Sex Hormones, Personality, and Eating Pathology.Brain sciences · 2023Review
- Binge Eating Risk During Midlife and the Menopausal Transition: Sensitivity to Ovarian Hormones as Potential Mechanisms of Risk.Current psychiatry reports · 2023Review
- Linking drug and food addiction: an overview of the shared neural circuits and behavioral phenotype.Frontiers in behavioral neuroscience · 2023Review
- Endocannabinoid System Regulation in Female Rats with Recurrent Episodes of Binge Eating.International journal of molecular sciences · 2022Article
- Combined oral contraceptive use and risk for binge eating in women: Potential gene × hormone interactions.Frontiers in neuroendocrinology · 2022Review
- Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice.Alcoholism, clinical and experimental research · 2022Article
- A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior.Biological psychiatry · 2022Review
- Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Because binge eating and emotional eating vary through the menstrual cycle in human females, we investigated cyclic changes in binge-like eating in female rats and their control by estrogens. Binge-like eating was elicited by three cycles of 4 days of food restriction and 4 days of free feeding followed by a single frustrative nonreward-stress episode (15 min visual and olfactory exposure to a familiar palatable food) immediately before presentation of the palatable food. Intact rats showed binge-like eating during the diestrous and proestrous phases of the ovarian cycle, but not during the estrous (periovulatory) phase. Ovariectomized (OVX) rats not treated with estradiol (E2) displayed binge-like eating, whereas E2-treated OVX rats did not. The procedure did not increase signs of anxiety in an open-field test. OVX rats not treated with E2 that were subjected to food restriction and sacrificed immediately after frustrative nonreward had increased numbers of cells expressing phosphorylated extracellular signal-regulated kinases (ERK) in the central nucleus of the amygdala (CeA), paraventricular nucleus of hypothalamus (PVN), and dorsal and ventral bed nuclei of the stria terminalis (BNST) compared with nonrestricted or E2-treated rats. These data suggest that this female rat model is appropriate for mechanistic studies of some aspects of menstrual-cycle effects on emotional and binge eating in human females, that anxiety is not a sufficient cause of binge-like eating, and that the PVN, CeA, and BNST may contribute to information processing underlying binge-like eating.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.