Trial reportJournal of perinatology : official journal of the California Perinatal Association2017
Sudden versus gradual pressure wean from Nasal CPAP in preterm infants: a randomized controlled trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Eligible Infants Included in Neonatal Clinical Trials and Reasons for Noninclusion: A Systematic Review.JAMA network open · 2024Pooled it
- Race and Ethnicity of Infants Enrolled in Neonatal Clinical Trials: A Systematic Review.JAMA network open · 2023Pooled it
- Weaning strategies for the withdrawal of non-invasive respiratory support applying continuous positive airway pressure in preterm infants: a systematic review and meta-analysis.BMJ paediatrics open · 2020Pooled it
- Extended CPAP or low-flow nasal cannula for intermittent hypoxaemia in preterm infants: a 24-hour randomised clinical trial.Archives of disease in childhood. Fetal and neonatal edition · 2024Trial
- A comparison of methods of discontinuing nasal CPAP in premature infants <30 weeks gestation: a feasibility study.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Sudden vs Pressure Wean From Nasal Continuous Positive Airway Pressure in Infants Born Before 32 Weeks of Gestation: A Randomized Clinical Trial.JAMA pediatrics · 2018Trial
- Structured continuous positive airway pressure weaning standardizes discontinuation and reduces instability events.Frontiers in pediatrics · 2026Article
- Extending CPAP in stable preterm infants to increase lung growth and development as measured by pulmonary function testing.Seminars in perinatology · 2025Review
- Comparison of Two Methods for Weaning from Nasal Continuous Positive Airway Pressure via the Cyclic Use of High-Flow Nasal Cannula or Room Air in Preterm Infants.Children (Basel, Switzerland) · 2024Article
- Complications associated with incorrect use of nasal CPAP.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Use of noninvasive mechanical ventilation weaning protocol in neonatal intensive care units in Brazil: a descriptive study.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Article
- Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Helmet CPAP to Treat Acute Hypoxemic Respiratory Failure in Patients with COVID-19: A Management Strategy Proposal.Journal of clinical medicine · 2020Article
- Practical aspects on the use of non-invasive respiratory support in preterm infants.International journal of pediatrics & adolescent medicine · 2020Review
- Bubble Nasal Continuous Positive Airway Pressure (bNCPAP): An Effective Low-Cost Intervention for Resource-Constrained Settings.International journal of pediatrics · 2020Review
- Continuous pulse oximetry and respiratory rate trends predict short-term respiratory and growth outcomes in premature infants.Pediatric research · 2019Article
- Turkish Neonatal Society guideline on the management of respiratory distress syndrome and surfactant treatment.Turk pediatri arsivi · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIn preterm infants, nasal continuous positive airway pressure (NCPAP) is widely used for treatment of respiratory distress syndrome. However, the strategies for successfully weaning infants off NCPAP are still not well defined and there remains considerable variation between the methods. The objective of this study is to determine whether gradual weaning of NCPAP pressure is more successful than sudden weaning off NCPAP to room air. STUDY
designA randomized controlled trial was conducted in a level 3 neonatal intensive care unit on 70 preterm neonates who were born between 26 and 32 weeks gestation and required NCPAP for at least 48 h. When infants were stable on NCPAP at 0.21 FiO
resultsOf the 70 infants included in the study, 35 were randomized to sudden group and 33 infants to gradual group (2 excluded for protocol deviation). In sudden and gradual groups, 14 and 22 infants, respectively, were weaned successfully in the first attempt (P=0.03). The infants were successfully weaned at 32.7±1.7 weeks versus 33.1±2.4 weeks (P=0.39) PMA and at a weight of 1651±290 g versus 1589±398 g (P=0.46) in the sudden and gradual groups, respectively. The total number of days on NCPAP was 27±19 days versus 32±24 days (P=0.38) and LOS was 63±25 days versus 63±22 days (P=0.99) in the sudden and gradual groups, respectively.
conclusionsGradual weaning method was more successful as compared to sudden weaning method in the initial trial off NCPAP. There was no difference in the PMA, weight at the time of successful wean, total days on NCPAP and LOS between the two groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.