ArticleTransplantation2017
Peritransplant Energy Changes and Their Correlation to Outcome After Human Liver Transplantation.
Article in Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Mitochondrial hyperoxidation contributes to warm ischemia-reperfusion injury in rat and pig livers.Communications medicine · 2026Article
- Cryopreservation Strategies to Improve Access to Organ Transplantation.Transplantation · 2026Review
- Gradual rewarming with a hemoglobin-based oxygen carrier improves viability of donation after circulatory death in rat livers.Frontiers in transplantation · 2024Article
- Current practice and novel approaches in organ preservation.Frontiers in transplantation · 2023Review
- Partial freezing of rat livers extends preservation time by 5-fold.Nature communications · 2022Article
- Modeling energy depletion in rat livers using Nash equilibrium metabolic pathway analysis.Scientific reports · 2022Article
- Optimization of Ex Vivo Machine Perfusion and Transplantation of Vascularized Composite Allografts.The Journal of surgical research · 2022Article
- Non-invasive quantification of the mitochondrial redox state in livers during machine perfusion.PloS one · 2021Article
- Integrative Network Analysis Revealed Genetic Impact of Pyruvate Kinase L/R on Hepatocyte Proliferation and Graft Survival after Liver Transplantation.Oxidative medicine and cellular longevity · 2021Article
- Subzero non-frozen preservation of human livers in the supercooled state.Nature protocols · 2020Article
- Cell release during perfusion reflects cold ischemic injury in rat livers.Scientific reports · 2020Article
- Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions.Journal of clinical medicine · 2020Article
- The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model.Artificial organs · 2020Article
- Article
- Beneficial effects of the novel marine oxygen carrier M101 during cold preservation of rat and human pancreas.Journal of cellular and molecular medicine · 2019Article
- Supercooling extends preservation time of human livers.Nature biotechnology · 2019Article
- Systems engineering the organ preservation process for transplantation.Current opinion in biotechnology · 2019Review
- Article
- Endothelial Dysfunction in Steatotic Human Donor Livers: A Pilot Study of the Underlying Mechanism During Subnormothermic Machine Perfusion.Transplantation direct · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe ongoing shortage of donor livers for transplantation and the increased use of marginal livers necessitate the development of accurate pretransplant tests of viability. Considering the importance energy status during transplantation, we aimed to correlate peritransplant energy cofactors to posttransplant outcome and subsequently model this in an ex vivo setting.
methodsSequential biopsies were taken from 19 donor livers postpreservation, as well as 30 minutes after portal venous reperfusion and hepatic arterial reperfusion and analyzed by liquid chromatography-mass spectrometry for energetic cofactors (adenosine triphosphate [ATP]/adenosine diphosphate [ADP]/adenosine monophosphate [AMP], nicotinamide adenine dinucleotide /NAD, nicotinamide adenine dinucleotide phosphate / nicotinamide adenine dinucleotide phosphate , flavin adenine dinucleotide , glutathione disulfide/glutathione). Energy status was correlated to posttransplant outcome. In addition, 4 discarded human donation after circulatory death livers were subjected to ex vivo reperfusion, modeling reperfusion injury and were similarly analyzed for energetic cofactors.
resultsA rapid shift toward higher energy adenine nucleotides was observed following clinical reperfusion, with a 2.45-, 3.17- and 2.12-fold increase in ATP:ADP, ATP:AMP and energy charge after portal venous reperfusion, respectively. Seven of the 19 grafts developed early allograft dysfunction. Correlation with peritransplant cofactors revealed a significant difference in EC between early allograft dysfunction and normal functioning grafts (0.09 vs 0.31, P < 0.05). In the simulated reperfusion model, a similar trend in adenine nucleotide changes was observed.
conclusionsA preserved energy status appears critical in the peritransplant period. Levels of adenine nucleotides change rapidly after reperfusion and ratios of ATP/ADP/AMP after reperfusion are significantly correlated to graft function. Using these markers as a viability test in combination with ex vivo reperfusion may provide a useful predictor of outcome that incorporates donor, preservation, and reperfusion factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.