Evidence map›Paper›PMID 28230352›Full record

ArticleACS chemical neuroscience2017

Disease-Modifying Effects of M

Evan P Lebois, Jason P Schroeder, Thomas J Esparza, Thomas M Bridges, Craig W Lindsley, P Jeffrey Conn, David L Brody, J Scott Daniels, Allan I Levey

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma.Journal of cellular and molecular medicine · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Behaviour Hallmarks in Alzheimer's Disease 5xFAD Mouse Model.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. MScience signaling · 2022
    Article
  11. Article
  12. Review
  13. Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Article
  15. Effects of muscarinic MNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  16. Review
  17. Review
  18. Biased MScience signaling · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jason P Schroeder
Thomas J EsparzaDepartment of Neurology, Washington University , St. Louis, Missouri 63130, United States.
Thomas M BridgesVanderbilt Center for Neuroscience Drug Discovery , Nashville, Tennessee 37067, United States.
Craig W LindsleyVanderbilt Center for Neuroscience Drug Discovery , Nashville, Tennessee 37067, United States.ORCID 0000-0003-0168-1445
P Jeffrey ConnVanderbilt Center for Neuroscience Drug Discovery , Nashville, Tennessee 37067, United States.
David L BrodyDepartment of Neurology, Washington University , St. Louis, Missouri 63130, United States.
J Scott DanielsVanderbilt Center for Neuroscience Drug Discovery , Nashville, Tennessee 37067, United States.
Allan I LeveyAlzheimer's Disease Research Center, Emory University , Atlanta, Georgia 30329, United States.

Funding

The Vanderbilt Specialized Chemistry Center for Accelerated Probe DevelopmentU54MH084659 · NIMH · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2008 to 2013
$24.1M
Vanderbilt NCDDDG for Discovery of Novel Treatments for SchizophreniaU01MH087965 · NIMH · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY, LINDSLEY, CRAIG · 2010 to 2014
$9.3M
Muscarinic receptor activators as novel antipsychotic agentsR01MH073676 · NIMH · VANDERBILT UNIVERSITY · PI Jerri Michelle Rook · 2006 to 2026
$9.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MIRNICS, KAROLY · 2015 to 2019
$7.1M
TRAINING IN TRANSLATIONAL RESEARCH IN NEUROLOGYT32NS007480 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2000 to 2020
$4.5M
Selective M1 mAChR allosteric modulators for the treatment of schizophreniaR01MH082867 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2008 to 2017
$3.7M
Mechanisms Underlying Tauopathy Following Traumatic Brain InjuryR01NS065069 · NINDS · WASHINGTON UNIVERSITY · PI BRODY, DAVID L · 2009 to 2017
$3.3M
Muscarinic Receptors in Alzheimer's DiseaseR01NS030454 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 1991 to 2009
$2.9M
NICHD NIH HHS U54 HD083211NIMH NIH HHS R01 MH073676NIMH NIH HHS R01 MH082867NIMH NIH HHS U01 MH087965NIMH NIH HHS U54 MH084659NINDS NIH HHS R01 NS030454NINDS NIH HHS R01 NS065069NINDS NIH HHS T32 NS007480
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the leading cause of dementia worldwide, and currently no disease-modifying therapy is available to slow or prevent AD, underscoring the urgent need for neuroprotective therapies. Selective M

Indexed as

Alzheimer DiseaseAnimalsBenzamidesBiphenyl CompoundsBrainMaze LearningMiceMice, TransgenicNeuroprotective AgentsReceptor, Muscarinic M1BenzamidesBiphenyl CompoundsNeuroprotective AgentsReceptor, Muscarinic M1VU0364572acetylcholineAlzheimer’samyloidhippocampusmemoryMuscarinic

Identifiers

PMID28230352
PMCPMC5808561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.