Evidence map›Paper›PMID 28230232›Full record

ArticleEpilepsia2017

Carisbamate blockade of T-type voltage-gated calcium channels.

Do Young Kim, Fang-Xiong Zhang, Stan T Nakanishi, Timothy Mettler, Ik-Hyun Cho, Younghee Ahn, Florian Hiess, Lina Chen, Patrick G Sullivan, S R Wayne Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Do Young KimDepartments of Neurology and Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital & Medical Center, Phoenix, Arizona, U.S.A.
Fang-Xiong ZhangDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Stan T NakanishiDepartment of Biology, University of Hawaii at Hilo, Hilo, Hawaii, U.S.A.
Timothy MettlerDepartments of Neurology and Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital & Medical Center, Phoenix, Arizona, U.S.A.
Ik-Hyun ChoDepartments of Neurology and Neurobiology, Barrow Neurological Institute, St. Joseph's Hospital & Medical Center, Phoenix, Arizona, U.S.A.
Younghee AhnDepartment of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Florian HiessDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Lina ChenDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Patrick G SullivanSpinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, U.S.A.
S R Wayne ChenDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Gerald W ZamponiDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Jong M RhoDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

Funding

Metabolic Mechanisms of Functional Neuroprotection in Epileptic BrainR01NS070261 · NINDS · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI KIM, DO YOUNG · 2010 to 2014
$1.6M
CIHRNINDS NIH HHS R01 NS070261
6 · The paper itself

Abstract

objectivesCarisbamate (CRS) is a novel monocarbamate compound that possesses antiseizure and neuroprotective properties. However, the mechanisms underlying these actions remain unclear. Here, we tested both direct and indirect effects of CRS on several cellular systems that regulate intracellular calcium concentration [Ca

methodsWe used a combination of cellular electrophysiologic techniques, as well as cell viability, Store Overload-Induced Calcium Release (SOICR), and mitochondrial functional assays to determine whether CRS might affect [Ca

resultsIn CA3 pyramidal neurons, kainic acid induced significant elevations in [Ca SIGNIFICANCE: Our data indicate that the neuroprotective and antiseizure activity of CRS likely results in part from decreased [Ca

Indexed as

AnimalsAnticonvulsantsCalciumCalcium Channels, T-TypeCarbamatesCells, CulturedCell SurvivalDose-Response Relationship, DrugExcitatory Amino Acid AgonistsGlutamic AcidHEK293 CellsHippocampusHumansIn Vitro TechniquesKainic AcidMale4-aminopiperidineAnticonvulsantsCalciumCalcium Channels, T-TypeCarbamatesExcitatory Amino Acid AgonistsGlutamic AcidKainic AcidPiperidinesPotassium Channel BlockersS-2-O-carbamoyl-1-o-chlorophenyl-ethanolCalciumCarisbamateEndoplasmic reticulumKainic acidMechanismMitochondriaNeuroprotectionRyanodine receptorT-type calcium channel

Identifiers

PMID28230232
PMCPMC5386822

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.