Evidence map›Paper›PMID 28230201›Full record

ArticleScientific reports2017

Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL.

Winde Jorissen, Elien Wouters, Jeroen F Bogie, Tim Vanmierlo, Jean-Paul Noben, Denis Sviridov, Niels Hellings, Veerle Somers, Roland Valcke, Bart Vanwijmeersch and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 56 citations in OpenAlex.

  1. Trial
  2. Article
  3. The Role of Lipid Alteration in Multiple Sclerosis.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Observational
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Perilipin-2 limits remyelination by preventing lipid droplet degradation.Cellular and molecular life sciences : CMLS · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. The Impact of Multiple Sclerosis Disease Status and Subtype on Hematological Profile.International journal of environmental research and public health · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Winde JorissenHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Elien WoutersHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Jeroen F BogieHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Tim VanmierloHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Jean-Paul NobenHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Denis SviridovNIH, Dept. of Laboratory Medicine, Clinical Center, Bethesda, United States.
Niels HellingsHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Veerle SomersHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Roland ValckeHasselt University, Faculty of Sciences, Molecular and Physical Plant Physiology, Diepenbeek, Belgium.
Bart VanwijmeerschRevalidation and MS Center, Overpelt, Belgium.
Piet StinissenHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Monique T MulderErasmus MC, Dept. of Vasc. and Met. diseases, Rotterdam, the Netherlands.
Alan T RemaleyNIH, Dept. of Laboratory Medicine, Clinical Center, Bethesda, United States.
Jerome J A HendriksHasselt University, Dept. of Immunology and Biochemistry, Biomed, Diepenbeek, Belgium.
Hasselt University · BENational Institutes of Health Clinical Center · USErasmus University Rotterdam · NLNational MS Center Melsbroek

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoproteins modulate innate and adaptive immune responses. In the chronic inflammatory disease multiple sclerosis (MS), reports on lipoprotein level alterations are inconsistent and it is unclear whether lipoprotein function is affected. Using nuclear magnetic resonance (NMR) spectroscopy, we analysed the lipoprotein profile of relapsing-remitting (RR) MS patients, progressive MS patients and healthy controls (HC). We observed smaller LDL in RRMS patients compared to healthy controls and to progressive MS patients. Furthermore, low-BMI (BMI ≤ 23 kg/m

Indexed as

Adaptive ImmunityAdultApolipoprotein A-IATP Binding Cassette Transporter, Subfamily G, Member 1Body Mass IndexCase-Control StudiesCholesterol, LDLCholesterol, VLDLDisease ProgressionFemaleGene ExpressionHumansImmunity, InnateInsulin ResistanceLipoproteins, HDLMagnetic Resonance SpectroscopyAPOA1 protein, humanApolipoprotein A-IATP Binding Cassette Transporter, Subfamily G, Member 1Cholesterol, LDLCholesterol, VLDLLipoproteins, HDLTriglycerides

Identifiers

PMID28230201
PMCPMC5322497
OpenAlexW2589500661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.