ArticleScientific reports2017
Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
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- Comparing statistical learning methods for complex trait prediction from gene expression.PloS one · 2025Article
- Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response.Genetics · 2023Article
- Chitinase-3-like 1 regulates TFrontiers in immunology · 2023Article
- Entomoculture: A Preliminary Techno-Economic Assessment.Foods (Basel, Switzerland) · 2022Article
- Establishment and a comparative transcriptomic analysis of a male-specific cell line from the African malaria mosquito Anopheles gambiae.Scientific reports · 2022Article
- Effects of abiotic stresses on the expression of chitinase-like genes inFrontiers in physiology · 2022Article
- A comparative analysis ofCurrent research in insect science · 2022Article
- Review
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- Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism.PLoS genetics · 2020Article
- Imaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori.PLoS genetics · 2020Article
- Chitotriosidase: a marker and modulator of lung disease.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Imaginal Disc Growth Factor 6 (Idgf6) Is Involved in Larval and Adult Wing Development inFrontiers in genetics · 2020Article
- Transcriptome of pleuropodia from locust embryos supports that these organs produce enzymes enabling the larva to hatch.Frontiers in zoology · 2020Article
- Expansion of Imaginal Disc Growth Factor Gene Family in Diptera Reflects the Evolution of Novel Functions.Insects · 2019Article
- The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization.EMBO reports · 2018Article
- Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects inGenetics · 2017Article
- Using theFrontiers in pediatrics · 2017Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila imaginal disc growth factor 2 (IDGF2) is a member of chitinase-like protein family (CLPs) able to induce the proliferation of imaginal disc cells in vitro. In this study we characterized physiological concentrations and expression of IDGF2 in vivo as well as its impact on the viability and transcriptional profile of Drosophila cells in vitro. We show that IDGF2 is independent of insulin and protects cells from death caused by serum deprivation, toxicity of xenobiotics or high concentrations of extracellular adenosine (Ado) and deoxyadenosine (dAdo). Transcriptional profiling suggested that such cytoprotection is connected with the induction of genes involved in energy metabolism, detoxification and innate immunity. We also show that IDGF2 is an abundant haemolymph component, which is further induced by injury in larval stages. The highest IDGF2 accumulation was found at garland and pericardial nephrocytes supporting its role in organismal defence and detoxification. Our findings provide evidence that IDGF2 is an important trophic factor promoting cellular and organismal survival.
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