ArticleScientific reports2017
Phylogenetic Characterizations of Highly Mutated EV-B106 Recombinants Showing Extensive Genetic Exchanges with Other EV-B in Xinjiang, China.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Genetic variation, recombinant characteristics, and seroprevalence analysis of echovirus 3 causing severe and mild cases of hand, foot, and mouth disease in Guizhou Province.Microbiology spectrum · 2026Article
- Genetic characterization and molecular evolution of type 3 vaccine-derived polioviruses from an immunodeficient patient in China.Virus research · 2023Article
- Molecular Characteristics and Genetic Evolution of Echovirus 33 in Mainland of China.Pathogens (Basel, Switzerland) · 2022Article
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- Molecular characterization of echovirus 9 strains isolated from hand-foot-and-mouth disease in Kunming, Yunnan Province, China.Scientific reports · 2022Article
- A novel interspecies recombinant enterovirus (Enterovirus A120) isolated from a case of acute flaccid paralysis in China.Emerging microbes & infections · 2020Article
- Genomic epidemiology of coxsackievirus A16 in mainland of China, 2000-18.Virus evolution · 2020Article
- Molecular typing and characterization of a novel genotype of EV-B93 isolated from Tibet, China.PloS one · 2020Article
- Molecular Epidemiological, Serological, and Pathogenic Analysis of EV-B75 Associated With Acute Flaccid Paralysis Cases in Tibet, China.Frontiers in microbiology · 2020Article
- Identification of a new recombinant strain of echovirus 33 from children with hand, foot, and mouth disease complicated by meningitis in Yunnan, China.Virology journal · 2019Article
- Phylogenetic analysis and phenotypic characterisatics of two Tibet EV-C96 strains.Virology journal · 2019Article
- Genetic characterization and molecular epidemiological analysis of novel enterovirus EV-B80 in China.Emerging microbes & infections · 2018Article
- Molecular characterization of echovirus 12 strains isolated from healthy children in China.Scientific reports · 2018Article
- Antigenic characteristics and genomic analysis of novel EV-A90 enteroviruses isolated in Xinjiang, China.Scientific reports · 2018Article
- Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease.Scientific reports · 2017Article
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10 authors.
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Abstract
Human enterovirus B106 (EV-B106) is a new member of the enterovirus B species. To date, only three nucleotide sequences of EV-B106 have been published, and only one full-length genome sequence (the Yunnan strain 148/YN/CHN/12) is available in the GenBank database. In this study, we conducted phylogenetic characterisation of four EV-B106 strains isolated in Xinjiang, China. Pairwise comparisons of the nucleotide sequences and the deduced amino acid sequences revealed that the four Xinjiang EV-B106 strains had only 80.5-80.8% nucleotide identity and 95.4-97.3% amino acid identity with the Yunnan EV-B106 strain, indicating high mutagenicity. Similarity plots and bootscanning analyses revealed that frequent intertypic recombination occurred in all four Xinjiang EV-B106 strains in the non-structural region. These four strains may share a donor sequence with the EV-B85 strain, which circulated in Xinjiang in 2011, indicating extensive genetic exchanges between these strains. All Xinjiang EV-B106 strains were temperature-sensitive. An antibody seroprevalence study against EV-B106 in two Xinjiang prefectures also showed low titres of neutralizing antibodies, suggesting limited exposure and transmission in the population. This study contributes the whole genome sequences of EV-B106 to the GenBank database and provides valuable information regarding the molecular epidemiology of EV-B106 in China.
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