ArticleNature communications2017
Compiler-aided systematic construction of large-scale DNA strand displacement circuits using unpurified components.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- DNA-Based Boolean Logic Gates for Molecular Computation and Biosensing: A Critical Review.Molecular biotechnology · 2026Review
- An Analysis of the Governance, Ethical, Legal, and Social Implications of Biocomputing.Science and engineering ethics · 2026Article
- Interpretable molecular decision-making with DNA-based scalable and memory-efficient tree computation.Nature communications · 2025Article
- Article
- Supervised learning in DNA neural networks.Nature · 2025Article
- Controlling DNA-RNA strand displacement kinetics with base distribution.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- Accelerating DNA computing via freeze-thaw cycling.Science advances · 2023Article
- Unlocking Genetic Profiles with a Programmable DNA-Powered Decoding Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A Theoretical Framework for Implementable Nucleic Acids Feedback Systems.Bioengineering (Basel, Switzerland) · 2023Article
- Mapping Temporally Ordered Inputs to Binary Message Outputs with a DNA Temporal Logic Circuit.Nanomaterials (Basel, Switzerland) · 2023Article
- Engineering DNA-based synthetic condensates with programmable material properties, compositions, and functionalities.Science advances · 2022Article
- Coarse-Grained Simulations for the Characterization and Optimization of Hybrid Protein-DNA Nanostructures.ACS nano · 2022Article
- DNA Strand-Displacement Temporal Logic Circuits.Journal of the American Chemical Society · 2022Article
- Catalyst-based biomolecular logic gates.Catalysts (Basel, Switzerland) · 2022Article
- Molecular communication relays for dynamic cross-regulation of self-sorting fibrillar self-assemblies.Science advances · 2021Article
- A Loser-Take-All DNA Circuit.ACS synthetic biology · 2021Article
- A Cooperative DNA Catalyst.Journal of the American Chemical Society · 2021Article
- Dynamic self-assembly of compartmentalized DNA nanotubes.Nature communications · 2021Article
- Cross-Inhibitor: a time-sensitive molecular circuit based on DNA strand displacement.Nucleic acids research · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biochemical circuits made of rationally designed DNA molecules are proofs of concept for embedding control within complex molecular environments. They hold promise for transforming the current technologies in chemistry, biology, medicine and material science by introducing programmable and responsive behaviour to diverse molecular systems. As the transformative power of a technology depends on its accessibility, two main challenges are an automated design process and simple experimental procedures. Here we demonstrate the use of circuit design software, combined with the use of unpurified strands and simplified experimental procedures, for creating a complex DNA strand displacement circuit that consists of 78 distinct species. We develop a systematic procedure for overcoming the challenges involved in using unpurified DNA strands. We also develop a model that takes synthesis errors into consideration and semi-quantitatively reproduces the experimental data. Our methods now enable even novice researchers to successfully design and construct complex DNA strand displacement circuits.
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Registered trials
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