ArticleNature communications2017
Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Minimising mutation load as a mechanism for low-dose hyper-radiosensitivity and induced radioresistance.Scientific reports · 2026Article
- What sets the mutation rate of a cell type in an animal species?PLoS biology · 2026Article
- What sets the mutation rate of a cell type in an animal species?bioRxiv : the preprint server for biology · 2025Article
- Negligible Long-Term Impact of Nonlinear Growth Dynamics on Heterogeneity in Models of Cancer Cell Populations.Bulletin of mathematical biology · 2025Article
- The dark side of stemness - the role of hematopoietic stem cells in development of blood malignancies.Frontiers in oncology · 2024Review
- Updating the Definition of Cancer.Molecular cancer research : MCR · 2023Article
- Self-supervised deep clustering of single-cell RNA-seq data to hierarchically detect rare cell populations.Briefings in bioinformatics · 2023Article
- Predicting the number of lifetime divisions for hematopoietic stem cells from telomere length measurements.iScience · 2023Article
- The structure of the hematopoietic system can explain chronic myeloid leukemia progression.Scientific reports · 2023Article
- Why are cell populations maintained via multiple compartments?Journal of the Royal Society, Interface · 2022Article
- Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization.Nature communications · 2022Article
- Telomeres, aging, and cancer: the big picture.Blood · 2022Article
- Constrained optimization of divisional load in hierarchically organized tissues during homeostasis.Journal of the Royal Society, Interface · 2022Article
- Normal tissue architecture determines the evolutionary course of cancer.Nature communications · 2021Article
- Identification of TOR-responsive slow-cycling neoblasts in planarians.EMBO reports · 2021Article
- Does Shoot Apical Meristem Function as the Germline in Safeguarding Against Excess of Mutations?Frontiers in plant science · 2021Review
- Review
- An in Situ Atlas of Mitochondrial DNA in Mammalian Tissues Reveals High Content in Stem and Proliferative Compartments.The American journal of pathology · 2020Article
- A compartment size-dependent selective threshold limits mutation accumulation in hierarchical tissues.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How can tissues generate large numbers of cells, yet keep the divisional load (the number of divisions along cell lineages) low in order to curtail the accumulation of somatic mutations and reduce the risk of cancer? To answer the question we consider a general model of hierarchically organized self-renewing tissues and show that the lifetime divisional load of such a tissue is independent of the details of the cell differentiation processes, and depends only on two structural and two dynamical parameters. Our results demonstrate that a strict analytical relationship exists between two seemingly disparate characteristics of self-renewing tissues: divisional load and tissue organization. Most remarkably, we find that a sufficient number of progressively slower dividing cell types can be almost as efficient in minimizing the divisional load, as non-renewing tissues. We argue that one of the main functions of tissue-specific stem cells and differentiation hierarchies is the prevention of cancer.
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