ArticleNature communications2017
Gel phase formation in dilute triblock copolyelectrolyte complexes.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Self-Healing and pH-Robust Hydrogels Enabled by Synergistic Supramolecular Interactions for Injectable Gastrointestinal Wound Repair.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Review
- Microstructural Rearrangements in Triblock Polyelectrolyte Complex Hydrogels.ACS macro letters · 2025Article
- Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications.ACS biomaterials science & engineering · 2024Review
- Bridge-rich and loop-less hydrogel networks through suppressed micellization of multiblock polyelectrolytes.Nature communications · 2024Article
- Effect of Polymer Gel Elasticity on Complex Coacervate Phase Behavior.ACS polymers Au · 2024Article
- Block Polyelectrolyte Additives That Modulate the Viscoelasticity and Enhance the Printability of Gelatin Inks at Physiological Temperatures.ACS applied polymer materials · 2024Article
- Advances, Applications, and Emerging Opportunities in Electrostatic Hydrogels.Langmuir : the ACS journal of surfaces and colloids · 2023Review
- Enhancement of polymer thermoresponsiveness and drug delivery across biological barriers by addition of small molecules.Heliyon · 2023Article
- Article
- A short peptide synthon for liquid-liquid phase separation.Nature chemistry · 2021Article
- Polyelectrolyte Complex Coacervation across a Broad Range of Charge Densities.Macromolecules · 2021Article
- Ion Pairing and the Structure of Gel Coacervates.Macromolecules · 2020Article
- Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles.Molecules (Basel, Switzerland) · 2020Article
- Formation of Asymmetric and Symmetric Hybrid Membranes of Lipids and Triblock Copolymers.Polymers · 2020Article
- Solvent-non-solvent rapid-injection for preparing nanostructured materials from micelles to hydrogels.Nature communications · 2019Article
- New frontiers for the materials genome initiative.npj computational materials · 2019Article
- Topologically frustrated dynamics of crowded charged macromolecules in charged hydrogels.Nature communications · 2018Article
- Relaxation Behavior by Time-Salt and Time-Temperature Superpositions of Polyelectrolyte Complexes from Coacervate to Precipitate.Gels (Basel, Switzerland) · 2018Article
- Complex Coacervation in Polyelectrolytes from a Coarse-Grained Model.ACS macro letters · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assembly of oppositely charged triblock copolyelectrolytes into phase-separated gels at low polymer concentrations (<1% by mass) has been observed in scattering experiments and molecular dynamics simulations. Here we show that in contrast to uncharged, amphiphilic block copolymers that form discrete micelles at low concentrations and enter a phase of strongly interacting micelles in a gradual manner with increasing concentration, the formation of a dilute phase of individual micelles is prevented in polyelectrolyte complexation-driven assembly of triblock copolyelectrolytes. Gel phases form and phase separate almost instantaneously on solvation of the copolymers. Furthermore, molecular models of self-assembly demonstrate the presence of oligo-chain aggregates in early stages of copolyelectrolyte assembly, at experimentally unobservable polymer concentrations. Our discoveries contribute to the fundamental understanding of the structure and pathways of complexation-driven assemblies, and raise intriguing prospects for gel formation at extraordinarily low concentrations, with applications in tissue engineering, agriculture, water purification and theranostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.