ReviewObesity (Silver Spring, Md.)2017
Biological control of appetite: A daunting complexity.
Review in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- A systematic review of ecological momentary assessment studies of appetite and affect in the experience of temptations and lapses during weight loss dieting.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- Trial
- Neuropeptide Y and peptide YY differentially modulate bitter- and fatty acid-evoked responses in human fungiform taste bud cells.American journal of physiology. Cell physiology · 2026Article
- Regulation of food intake by Connexin43 via adipocyte-sensory neuron electrical synapses.Molecular metabolism · 2025Article
- Appetite Self-Regulation in Childhood: A Narrative Review and Conceptual Model of Processes and Mechanisms With Implications for Research and Practice.Nutrition reviews · 2025Review
- Pathways linking BMI trajectories and mental health in an adult population-based cohort: role of emotional eating and body dissatisfaction.International journal of obesity (2005) · 2025Article
- Associations of Device-Measured Physical Activity and Sedentary Time With Neural Responses to Visual Food Cues in Adults: A Functional Magnetic Resonance Imaging Study.Human brain mapping · 2025Article
- Tying Food Addiction to Uncontrolled Eating: The Roles of Eating-Related Thoughts and Emotional Eating.Nutrients · 2025Article
- Perspectives on Healthy Eating of Adult Populations in High-Income Countries: A Qualitative Evidence Synthesis.International journal of behavioral medicine · 2024Review
- Cholesterol reduction by immunization with a PCSK9 mimic.Cell reports · 2024Article
- Assessing Discriminant Validity through Structural Equation Modeling: The Case of Eating Compulsivity.Nutrients · 2024Article
- Methanol extract ofJournal of animal science and technology · 2024Article
- Behavioural susceptibility theory: the role of appetite in genetic susceptibility to obesity in early life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Energy Balance and Bone Health: a Nutrient Availability Perspective.Current osteoporosis reports · 2023Review
- Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation.Current nutrition reports · 2022Review
- Metabolic reconstitution of germ-free mice by a gnotobiotic microbiota varies over the circadian cycle.PLoS biology · 2022Article
- The Role of Obesity and Diabetes in Dementia.International journal of molecular sciences · 2022Review
- Role of Leu72Met ofNutrients · 2022Article
- Microbiota and body weight control: Weight watchers within?Molecular metabolism · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThis review summarizes a portion of the discussions of an NIH Workshop (Bethesda, MD, 2015) titled "Self-Regulation of Appetite-It's Complicated," which focused on the biological aspects of appetite regulation.
methodsThis review summarizes the key biological inputs of appetite regulation and their implications for body weight regulation.
resultsThese discussions offer an update of the long-held, rigid perspective of an "adipocentric" biological control, taking a broader view that also includes important inputs from the digestive tract, from lean mass, and from the chemical sensory systems underlying taste and smell. It is only beginning to be understood how these biological systems are integrated and how this integrated input influences appetite and food eating behaviors. The relevance of these biological inputs was discussed primarily in the context of obesity and the problem of weight regain, touching on topics related to the biological predisposition for obesity and the impact that obesity treatments (dieting, exercise, bariatric surgery, etc.) might have on appetite and weight loss maintenance. Finally considered is a common theme that pervaded the workshop discussions, which was individual variability.
conclusionsIt is this individual variability in the predisposition for obesity and in the biological response to weight loss that makes the biological component of appetite regulation so complicated. When this individual biological variability is placed in the context of the diverse environmental and behavioral pressures that also influence food eating behaviors, it is easy to appreciate the daunting complexities that arise with the self-regulation of appetite.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.