ArticleBritish journal of clinical pharmacology2017
Initial medication non-adherence: prevalence and predictive factors in a cohort of 1.6 million primary care patients.
Article in British journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Implementation of a patient-centred complex intervention to improve Initial Medication Adherence to cardiovascular disease and diabetes treatments in primary care (the IMA-cRCT study): a mixed-methods process evaluation.BMJ quality & safety · 2026Trial
- Psychotropic medication non-adherence and its determinants among adult psychiatric patients in Ethiopia.Social psychiatry and psychiatric epidemiology · 2026Article
- Adherence to oral thromboprophylaxis in atrial fibrillation: an overview for clinicians.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- Medication adherence in the elderly population with chronic diseases: a factor analysis.Frontiers in pharmacology · 2025Article
- Non-dispensed prescriptions - A nationwide descriptive study.Exploratory research in clinical and social pharmacy · 2024Article
- Not obtaining a medication the first time it is prescribed: primary non-adherence to cardiovascular pharmacotherapy.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- Prevalence and Associated Factors of Medication Non-Adherence in CRS Patients following Endoscopic Sinus Surgery.Journal of clinical medicine · 2023Article
- Prevalence and predictors of primary nonadherence to medications prescribed in primary care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- Using the national electronic prescription system to determine the primary non-adherence to medication in the Czech Republic.Frontiers in pharmacology · 2023Article
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- Improving Initial Medication Adherence to cardiovascular disease and diabetes treatments in primary care: Pilot trial of a complex intervention.Frontiers in public health · 2022Article
- Pediatric Medication Noninitiation in Spain.Pediatrics · 2022Observational
- Machine Learning and Medication Adherence: Scoping Review.JMIRx med · 2021Article
- Is Prescription Nonredemption a Source of Poor Health Among the Roma? Cross-Sectional Analysis of Drug Consumption Data From the National Health Insurance Fund of Hungary.Frontiers in pharmacology · 2021Article
- The Need to Develop Standard Measures of Patient Adherence for Big Data: Viewpoint.Journal of medical Internet research · 2020Article
- Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors.International journal of environmental research and public health · 2020Article
- Medication adherence-Key considerations for clinical pharmacologists.British journal of clinical pharmacology · 2020Article
- Primary non-adherence to inhaled medications measured with e-prescription data from Poland.Clinical and translational allergy · 2020Article
- Primary Non-Adherence to Antihistamines-Conclusions From E-Prescription Pilot Data in Poland.Frontiers in pharmacology · 2020Article
Corrections and comments
- Erratum issuedCorrection.2018
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAdherence to medicines is vital in treating diseases. Initial medication non-adherence (IMNA) - defined as not obtaining a medication the first time it is prescribed - has been poorly explored. Previous studies show IMNA rates between 6 and 28% in primary care (PC). The aims of this study were to determine prevalence and predictive factors of IMNA in the most prescribed and expensive pharmacotherapeutic groups in the Catalan health system.
methodsThis is a retrospective, register-based cohort study which linked the Catalan PC System (Spain) prescription and invoicing databases. Medication was considered non-initiated when it was not collected from the pharmacy by the end of the month following the one in which it was prescribed. IMNA prevalence was calculated using July 2013-June 2014 prescription data. Predictive factors related to patients, general practitioners and PC centres were identified through multilevel logistic regression analyses. Missing data were attributed using simple imputation.
resultsSome 1.6 million patients with 2.9 million prescriptions were included in the study sample. Total IMNA prevalence was 17.6% of prescriptions. The highest IMNA rate was observed in anilides (22.6%) and the lowest in angiotensin-converting-enzyme (ACE) inhibitors (7.4%). Predictors of IMNA are younger age, American nationality, having a pain-related or mental disorder and being treated by a substitute/resident general practitioner in a resident-training centre.
conclusionsThe rate of IMNA is high when all medications are taken into account. Attempts to strengthen trust in resident general practitioners and improve motivation to initiate a needed medication in the general young and older immigrant population should be addressed in Catalan PC.
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