ArticleEndocrine2017
Thyroid hormone acting via TRβ induces expression of browning genes in mouse bone marrow adipose tissue.
Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2-Mediated Mitochondrial Fusion and UCP1-Mediated Lipid Browning in ccRCC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Critical Role of Adipocytes in Leukemia.Biology · 2025Review
- Cationic polymer effect on brown adipogenic induction of dedifferentiated fat cells.Materials today. Bio · 2024Article
- Sex-Specific Effects of THRβ Signaling on Metabolic Responses to High Fat Diet in Mice.Endocrinology · 2024Article
- Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts.Communications biology · 2024Article
- Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges.Pharmaceutics · 2023Review
- Pharmacological modulation of adaptive thermogenesis: new clues for obesity management?Journal of endocrinological investigation · 2023Review
- How does Hashimoto's thyroiditis affect bone metabolism?Reviews in endocrine & metabolic disorders · 2023Review
- Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases.Nutrition & metabolism · 2022Review
- Tissue Transglutaminase Knock-Out Preadipocytes and Beige Cells of Epididymal Fat Origin Possess Decreased Mitochondrial Functions Required for Thermogenesis.International journal of molecular sciences · 2022Article
- Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats.Frontiers in endocrinology · 2022Article
- Transdermal Drug Delivery Systems and Their Use in Obesity Treatment.International journal of molecular sciences · 2021Review
- Computational prediction of small molecules with predicted binding to FGFR3 and testing biological effects in bone cells.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Bone Marrow Adipocytes-Role in Physiology and Various Nutritional Conditions in Human and Animal Models.Nutrients · 2021Review
- Chronic stress and adipose tissue in the anorexic state: endocrine and epigenetic mechanisms.Adipocyte · 2020Review
- Skeletal effects of nongenomic thyroid hormone receptor beta signaling.The Journal of endocrinology · 2019Article
- Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism.Current molecular biology reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeMutant hypothyroid mouse models have recently shown that thyroid hormone is critical for skeletal development during an important prepubertal growth period. Additionally, thyroid hormone negatively regulates total body fat, consistent with the well-established effects of thyroid hormone on energy and fat metabolism. Since bone marrow mesenchymal stromal cells differentiate into both adipocytes and osteoblasts and a relationship between bone marrow adipogenesis and osteogenesis has been predicted, we hypothesized thyroid hormone deficiency during the postnatal growth period increases marrow adiposity in mice.
methodsMarrow adiposity in TH-deficient (Tshr
resultsMarrow adiposity increased >20% (P < 0.01) in Tshr
conclusionsThese data suggest that thyroid hormone regulation of marrow adiposity is mediated at least in part via activation of TRβ signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.