ArticleThe journal of headache and pain2017
Cerebral endothelial dysfunction in reversible cerebral vasoconstriction syndrome: a case-control study.
Article in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Profiling cerebrovascular function in migraine: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Review
- Systemic Arterial Stiffness in Reversible Cerebral Vasoconstriction Syndrome: A Prospective Case-Control Study.European journal of neurology · 2026Observational
- Short-term effects of air pollution and weather on reversible cerebral vasoconstriction syndrome: a retrospective bicenter study.Journal of neurology · 2025Article
- Familial Reversible Cerebral Vasoconstriction Syndrome: Insights From Two Families.Case reports in neurological medicine · 2025Article
- Reversible Cerebral Vasoconstriction Syndrome Secondary to Escitalopram.Clinical medicine & research · 2024Article
- Radiological Findings in Reversible Cerebral Vasoconstriction Syndrome: A Systematic Review of Literature.Cureus · 2024Review
- Concurrent spontaneous coronary dissection and reversible cerebral vasoconstriction syndrome during postnatal care.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Article
- Association between impaired dynamic cerebral autoregulation and BBB disruption in reversible cerebral vasoconstriction syndrome.The journal of headache and pain · 2023Article
- Reversible cerebral Vasoconstriction syndrome intERnational CollaborativE (REVERCE) network: Study protocol and rationale of a multicentre research collaboration.European stroke journal · 2023Article
- Headache Attributed to Reversible Cerebral Vasoconstriction Syndrome (RCVS).Diagnostics (Basel, Switzerland) · 2023Review
- Reversible Cerebral Vasoconstriction Syndrome Associated with Vasospasm of the Colic Arteries and Possibly Coronary Vasospasm.The American journal of case reports · 2023Article
- Pathophysiology of reversible cerebral vasoconstriction syndrome.Journal of biomedical science · 2022Review
- A Case Report of Reversible Cerebral Vasoconstriction Syndrome in a Patient With Systemic Scleroderma.Cureus · 2022Article
- Fatal reversible cerebral vasoconstriction syndrome: An unusual presentation of a rare diseaseBiomedica : revista del Instituto Nacional de Salud · 2021Article
- Post-reversible cerebral vasoconstriction syndrome headache.The journal of headache and pain · 2021Article
- Narrative Review: Headaches After Reversible Cerebral Vasoconstriction Syndrome.Current pain and headache reports · 2020Review
- Headache in cerebrovascular diseases.Stroke and vascular neurology · 2020Review
- No Association ofJournal of clinical neurology (Seoul, Korea) · 2020Article
- Reversible Cerebral Vasoconstriction Syndrome Associated with Coronary Artery Vasospasm.Texas Heart Institute journal · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS).
methodsWe prospectively recruited patients with RCVS, age-matched controls with episodic migraine, and age-matched healthy controls at Samsung Medical Center from Apr 2015 to Jul 2016. All participants underwent transcranial Doppler evaluation, with a breath-holding maneuver, for the evaluation of bilateral middle cerebral arteries (MCAs), posterior cerebral arteries (PCAs), and the basilar artery (BA). The breath-holding index (BHI) was used to measure cerebral endothelium-dependent vasodilation. Follow-up BHIs were recorded in selected patients with RCVS after 3 months.
resultsA total of 84 subjects were recruited for this study (n = 28 in each group of RCVS, episodic migraine, and healthy control; mean age, 49.8 years). The RCVS group showed lower BHIs in all basal arteries, in comparison to healthy controls (p < 0.001, 0.009 for bilateral MCAs, p < 0.001 and 0.028 for bilateral PCAs, and p = 0.060 for the BA). Compared to migraineurs, RCVS patients had lower BHIs only in the anterior circulation (p = 0.002 and 0.038 for bilateral MCAs; p = 0.069 and 0.247 for bilateral PCAs; p = 0.120 for the BA). Of the 10 patients who had follow-up BHIs at 3 months, 7 showed complete normalization, while three did not.
conclusionsCerebral endothelial function is impaired in a widespread distribution in RCVS. Its role in the pathogenesis and clinical outcome of RCVS should be determined in further studies.
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Registered trials
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