Evidence map›Paper›PMID 28229275›Full record

Trial reportJournal of cancer survivorship : research and practice2017

A pilot randomized trial to prevent sexual dysfunction in postmenopausal breast cancer survivors starting adjuvant aromatase inhibitor therapy.

Pragati Advani, Abenaa M Brewster, George P Baum, Leslie R Schover

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of cancer survivorship : research and practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06458764 unknown statusnot on this mapstarted 2023, after this paper: background citation

SEXCHECK - Sexual Dysfunction Check-up in Premenopausal Breast Cancer Survivors Taking Endocrine Therapy: A Cross-Sectional Study

Typeobservational_patient_registrySponsorCandiolo Cancer Institute - IRCCSRan2023 to 2025Enrolled150ConditionsBreast Cancer Female, Sexual Dysfunction, Premenopausal Breast CancerArmsQuestionnaire
NCT06900374 narecruitingnot on this mapstarted 2025, after this paper: background citation

RF-Vaginale : Randomised Phase III Trial Evaluating the Efficacy and Safety of Vaginal Radiofrequency in the Management of Vulvovaginal Atrophy and Dryness in Patients Treated for Breast Cancer

TypeinterventionalSponsorCentre Oscar LambretRan2025 to 2028Enrolled75ConditionsVaginal Dryness, Breast Cancer, Vulvovaginal AtrophyArmsGynWave-360, Local hydratation
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Management of genitourinary symptoms in patients with breast cancer: an updated systematic review of available evidence from randomized trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  3. Pooled it
  4. The effects of staged sexual health education on sexual and mental health in breast cancer patients: a randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  5. Trial
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  9. Review
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  13. Ovarian Suppression: Early Menopause and Late Effects.Current treatment options in oncology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pragati AdvaniDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Abenaa M BrewsterDepartment of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
George P BaumDepartment of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Leslie R SchoverDepartment of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA. lschover@gmail.com.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
6 · The paper itself

Abstract

purposeA randomized pilot trial evaluated the hypothesis that early intervention lessens sexual dysfunction in the first year on aromatase inhibitors. A secondary aim was comparing the efficacy of two vaginal moisturizers.

methodsFifty-seven postmenopausal women with early stage breast cancer starting aromatase inhibitors were randomized to three treatment groups. All received a handout on managing sexual and other side effects. The Usual Care group received no additional therapy. The Active Treatment groups received a 6-month supply of a vaginal moisturizer (hyaluronic acid-based in Active Group-H and prebiotic in Active Group-P) and a vaginal lubricant and dilator, plus access to an educational website and phone coaching. Questionnaires completed at baseline, 6, and 12 months included the Female Sexual Function Index (FSFI), Menopausal Sexual Interest Questionnaire (MSIQ), Female Sexual Distress Scale-Revised (FSDS-R), and a menopausal symptom scale.

resultsForty-nine women (86%) provided follow-up data. Mean age was 59 and 77% were non-Hispanic Caucasian. Sexual function was impaired at baseline, but remained stable over 12 months for all groups. The combined active treatment group had less dyspareunia (P = 0.07) and sexual distress (P = 0.02) at 6 months than the Usual Care group. At 6 months, the Active-H group improved significantly more than the Active-P group on FSFI total score (P = 0.04).

conclusionsSexual counseling helped women maintain stable sexual function on aromatase inhibitors. Active intervention resulted in better outcomes at 6 months. IMPLICATIONS FOR CANCER SURVIVORS: This promising pilot trial suggests a need for more research on preventive counseling to maintain sexual function during aromatase inhibitor treatment.

Indexed as

Aromatase InhibitorsBreast NeoplasmsFemaleHumansMiddle AgedPilot ProjectsPostmenopauseSexual BehaviorSurveys and QuestionnairesSurvivorsAromatase InhibitorsAromatase inhibitorsBreast cancerDyspareuniaGenitourinary atrophyPreventionSexual dysfunction

Identifiers

PMID28229275
OpenAlexW2590913744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.