Evidence map›Paper›PMID 28229273›Full record

SynthesisHeart failure reviews2017

Effect of exercise on diastolic function in heart failure patients: a systematic review and meta-analysis.

M J Pearson, S F Mungovan, N A Smart

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Heart failure reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06584734 (Effect of Intradialytic Exercise on Left Ventricular Diastolic Function in Hemodialysis Patients), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06584734 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of Intradialytic Exercise on Left Ventricular Diastolic Function in Hemodialysis Patients

TypeinterventionalSponsorInstituto Nacional de Cardiologia Ignacio ChavezRan2023 to 2024Enrolled30ConditionsRenal Dialysis, Hemodiafiltration, Diastolic Dysfunction, Kidney FailureArmsNot exercise, Exercise during hemodiafiltration session
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Cardiac Structure and Function in Adults with Down Syndrome.International journal of environmental research and public health · 2022
    Article
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  15. Review
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  17. Review
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  20. Brazilian Cardiovascular Rehabilitation Guideline - 2020.Arquivos brasileiros de cardiologia · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M J PearsonSchool of Science and Technology, University of New England, Armidale, NSW, 2351, Australia.
S F MungovanWestmead Private Physiotherapy Services and The Clinical Research Institute, Sydney, Australia.
N A SmartSchool of Science and Technology, University of New England, Armidale, NSW, 2351, Australia. nsmart2@une.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diastolic dysfunction contributes to the development and progression of heart failure. Conventional echocardiography and tissue Doppler imaging are widely utilised in clinical research providing a number of indices of diastolic function valuable in the diagnosis and prognosis of heart failure patients. The aim of this meta-analysis was to quantify the effect of exercise training on diastolic function in patients with heart failure. Exercise training studies that investigate different indices of diastolic function in patients with heart failure have reported that exercise training improves diastolic function in these patients. We sought to add to the current literature by quantifying, where possible, the effect of exercise training on diastolic function. We conducted database searches (PubMed, EBSCO, EMBASE, and Cochrane Trials Register to 31 July 2016) for exercise based rehabilitation trials in heart failure, using the search terms 'exercise training, diastolic function and diastolic dysfunction'. Data from six studies, with a total of 266 heart failure with reduced ejection fraction (HFrEF) participants, 144 in intervention groups and 122 in control groups, indicated a significant reduction in the ratio of early diastolic transmitral velocity (E) to early diastolic tissue velocity (E') (E/E' ratio) with exercise training, exercise vs. control mean difference (MD) of -2.85 (95% CI -3.66 to -2.04, p < 0.00001). Data from five studies in heart failure with preserved ejection fraction (HFpEF) patients, with a total of 204 participants, 115 in intervention groups and 89 in control groups, also demonstrated a significant improvement in E/E' in exercise vs. control MD of -2.38 (95% CI -3.47 to -1.28, p < 0.0001).

Indexed as

Heart Failure, DiastolicDiastoleEchocardiographyExercise TherapyExercise ToleranceHumansStroke VolumeTreatment OutcomeVentricular Function, LeftCardiac functionDiastolic functionExerciseHeart failure

Identifiers

PMID28229273

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.