ReviewNeurobiology of stress2017
Early life adversity: Lasting consequences for emotional learning.
Review in Neurobiology of stress, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04165473 (A Training Program for Developing Social- and Personal Resources and Its Effects on Emotional, Physical and Social Wellbeing in Adults), which is not on this map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Training Program for Developing Social- and Personal Resources and Its Effects on Emotional, Physical and Social Wellbeing in Adults
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive impairment and dementia-Are they linked to childhood health and socioeconomic status? A systematic review.PloS one · 2025Pooled it
- The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.British journal of anaesthesia · 2023Pooled it
- Aversive 22-kHz ultrasonic vocalization playback reveals differences in affective (dys)function following early life adversity in male and female juvenile rats.Behavioural brain research · 2026Article
- Impacts of the Early Collaborative Intervention on mother-preterm infant interaction at one month of age: Secondary analysis of a randomized controlled trial.International journal of nursing studies advances · 2026Article
- Promoting bonding and secure attachment in the NICU to improve parent-infant mental health: recommendations for clinical practice.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Adrenarche as a regulator of sensitivity to early adversity.Journal of neuroendocrinology · 2026Review
- Inflammatory mechanisms contribute to long-term cognitive deficits induced by perinatal asphyxia via interleukin-1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Impacts of early life adversity on the neurocircuitry of emotional memory in children.Development and psychopathology · 2025Article
- Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior.Neurobiology of stress · 2025Article
- The balance between care and conflict may be key to understanding maternal aggression in canaries.Scientific reports · 2025Article
- Mediating Role of Depression Severity in the Relationship Between Childhood Trauma and Non-Suicidal Self-Injury Among Adolescents With Mood Disorders.Brain and behavior · 2025Article
- FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice.Nature communications · 2025Article
- Left OFC Activation in Functional Near-Infrared Spectroscopy during an Inhibitory Control Task in an Early Years Sample: Integrating Stress Responses with Cognitive Function and Brain Activation.Developmental neuroscience · 2025Article
- Prenatal Stress Increases the Risk of the FPR2-related Dysfunction in the Brain's Resolution of Inflammation: A Study on the Humanized APPCurrent neuropharmacology · 2025Article
- Early-life risperidone alters locomotor responses to apomorphine and quinpirole in adulthood.Behavioural brain research · 2024Article
- The Yin and Yang of the oxytocin and stress systems: opposites, yet interdependent and intertwined determinants of lifelong health trajectories.Frontiers in endocrinology · 2024Article
- Early psychosocial parent-infant interventions and parent-infant relationships after preterm birth-a scoping review.Frontiers in psychology · 2024Article
- Relationship Between Neighborhood Poverty and Externalizing Symptoms in Children: Mediation and Moderation by Environmental Factors and Brain Structure.Child psychiatry and human development · 2023Article
- Neurodevelopmental, Mental Health, and Parenting Issues in Preterm Infants.Children (Basel, Switzerland) · 2023Article
- Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice.Nature communications · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early postnatal period is a highly sensitive time period for the developing brain, both in humans and rodents. During this time window, exposure to adverse experiences can lastingly impact cognitive and emotional development. In this review, we briefly discuss human and rodent studies investigating how exposure to adverse early life conditions - mainly related to quality of parental care - affects brain activity, brain structure, cognition and emotional responses later in life. We discuss the evidence that early life adversity hampers later hippocampal and prefrontal cortex functions, while increasing amygdala activity, and the sensitivity to stressors and emotional behavior later in life. Exposure to early life stress may thus on the one hand promote behavioral adaptation to potentially threatening conditions later in life -at the cost of contextual memory formation in less threatening situations- but may on the other hand also increase the sensitivity to develop stress-related and anxiety disorders in vulnerable individuals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.