ReviewNeurobiology of stress2017
Prenatal stressors in rodents: Effects on behavior.
Review in Neurobiology of stress, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
129 citing papers in PubMed, 1 synthesis or guideline pooled it, 255 citations in OpenAlex.
- How Early Life Stress Impact Maternal Care: A Systematic Review of Rodent Studies.Frontiers in behavioral neuroscience · 2019Pooled it
- Maternal Social Support Reshapes the Offspring Brain Transcriptome to Buffer Prenatal Stress in Mice.Research square · 2026Article
- Ventromedial hypothalamus IL-6 signaling mediates the excessive aggressive behavior induced by late-gestational sleep deprivation in male mice.Behavioral and brain functions : BBF · 2026Article
- Maternal depression and offspring neurodevelopmental impairments in wild rodents induced by ecologically relevant prenatal stress.Molecular psychiatry · 2026Article
- Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice.Journal of neuroendocrinology · 2026Article
- Air pollution and postpartum depression: the interplay with prenatal stress.Research square · 2026Article
- Enhancing Laboratory Animal Welfare through Motivational Training of Facility Personnel: A One Welfare Approach.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Animal models for the study of ADHD: the need for next-generation models.Frontiers in psychiatry · 2026Review
- Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus.Frontiers in molecular neuroscience · 2026Article
- Abnormal intestinal microbial colonization in prenatally stressed offspring is related to lung and intestinal cytokine expression.Frontiers in microbiology · 2026Article
- A biological and ethical assessment of whether humans could or should reproduce in space.NPJ microgravity · 2025Review
- Impact of Immobilization Stress on the Redox System in Prenatally Stressed Rats.Bulletin of experimental biology and medicine · 2025Article
- Associations among prenatal stress, socioeconomic status, and infant epigenetic aging.Psychoneuroendocrinology · 2025Article
- Dependence of psychopharmacological drug effects on early social stress experience: An analysis aligned with the research domain criteria framework.The Journal of pharmacology and experimental therapeutics · 2025Review
- Cortisol as a Mediator of Prenatal Distress and Difficult Infant Temperament: A Systematic Review and Meta-Analysis Protocol.Health science reports · 2025Article
- Prenatal betamethasone-postnatal N-methyl-D-aspartic acid model of spasms: Update on mechanisms and treatments.Epilepsia open · 2025Article
- Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities.Neurobiology of stress · 2025Article
- Paternal predatory risk alters parental behavior and offspring phenotypes in biparental Brandt's voles.Current zoology · 2025Article
- Personality development in non-domesticated house mice: evidence for a nutrition-dependent sensitive period early in life.Proceedings. Biological sciences · 2025Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current review focuses on studies in rodents published since 2008 and explores possible reasons for any differences they report in the effects of gestational stress on various types of behavior in the offspring. An abundance of experimental data shows that different maternal stressors in rodents can replicate some of the abnormalities in offspring behavior observed in humans. These include, anxiety, in juvenile and adult rats and mice, assessed in the elevated plus maze and open field tests and depression, detected in the forced swim and sucrose-preference tests. Deficits were reported in social interaction that is suggestive of pathology associated with schizophrenia, and in spatial learning and memory in adult rats in the Morris water maze test, but in most studies only males were tested. There were too few studies on the novel object recognition test at different inter-trial intervals to enable a conclusion about the effect of prenatal stress and whether any deficits are more prevalent in males. Among hippocampal glutamate receptors, NR2B was the only subtype consistently reduced in association with learning deficits. However, like in humans with schizophrenia and depression, prenatal stress lowered hippocampal levels of BDNF, which were closely correlated with decreases in hippocampal long-term potentiation. In mice, down-regulation of BDNF appeared to occur through the action of gene-methylating enzymes that are already increased above controls in prenatally-stressed neonates. In conclusion, the data obtained so far from experiments in rodents lend support to a physiological basis for the neurodevelopmental hypothesis of schizophrenia and depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.