Evidence map›Paper›PMID 28229074›Full record

ReviewVisceral medicine2016

Imaging of Cholangiocarcinoma.

Susann-Cathrin Olthof, Ahmed Othman, Stephan Clasen, Christina Schraml, Konstantin Nikolaou, Malte Bongers

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Visceral medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05172310 (PET Imaging of Tumors in Pancreas, Bile Ducts, Stomach and Ovaries by a Novel Tracer, 68Ga-FAPI-46 = Fibroblast Activation Protein Inhibitor), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05172310 phase1recruitingnot on this mapstarted 2021, after this paper: background citation

PET Imaging of Tumors in Pancreas, Bile Ducts, Stomach and Ovaries by a Novel Tracer, 68Ga-FAPI-46 = Fibroblast Activation Protein Inhibitor

TypeinterventionalSponsorKarolinska University HospitalRan2021 to 2029Enrolled410ConditionsPancreatic Neoplasms, Stomach Neoplasms, Bile Duct Neoplasms, Epithelial Ovarian CancerArms68Ga-FAPI-46, PET/CT
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Diagnostic Performance of Radiolabelled FAPI Versus [International journal of molecular sciences · 2025
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Comparison ofAbdominal radiology (New York) · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Cholangiocarcinoma: State of the Art.Journal of gastrointestinal cancer · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Susann-Cathrin OlthofDepartment of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany.
Ahmed OthmanDepartment of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany.
Stephan ClasenDepartment of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany.
Christina SchramlDepartment of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany.
Konstantin NikolaouDepartment of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany.
Malte BongersDepartment of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholangiocarcinoma (CC) is the second most common primary hepatobiliary tumour, and it is increasing in incidence. Imaging characteristics, behaviour, and therapeutic strategies in CC differ significantly, depending on the morphology and location of the tumour. In cross-sectional imaging, CCs can be classified according to the growth pattern (mass-forming, periductal infiltrating, intraductal) and the location (intrahepatic, perihilar, extrahepatic/distal). The prognosis of CC is unfavourable and surgical resection is the only curative treatment option; thus, early diagnosis (also in recurrent disease) and accurate staging including the evaluation of lymph node involvement and vascular infiltration is crucial. However, the diagnostic evaluation of CC is challenging due to the heterogeneous nature of the tumour. Diagnostic modalities used in the imaging of CC include transabdominal ultrasound, endosonography, computed tomography, magnetic resonance imaging with cholangiopancreatography, and hybrid imaging such as positron emission tomography/computed tomography. In this review, the potential of cross-sectional imaging modalities in primary staging, treatment monitoring, and detection of recurrent disease will be discussed.

Indexed as

CholangiocarcinomaComputed tomographyCross-sectional imagingMagnetic resonance imagingPositron emission tomography

Identifiers

PMID28229074
PMCPMC5290452
OpenAlexW2559894816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.