ArticleNutrition & metabolism2017
Hepatic iron storage is related to body adiposity and hepatic inflammation.
Article in Nutrition & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Modulation of hepcidin synthesis: the core link in the bi-directional relationship between iron and obesity.Reviews in endocrine & metabolic disorders · 2026Review
- The Impact of Iron Homeostasis in Insulin-Sensitive Tissues and Gut Microbiome on Obesity-Driven Metabolic Disorders.Advances in experimental medicine and biology · 2025Review
- Comparison between School-Age Children with and without Obesity in Nutritional and Inflammation Biomarkers.Journal of clinical medicine · 2022Article
- The role of iron metabolism in chronic diseases related to obesity.Molecular medicine (Cambridge, Mass.) · 2022Review
- Iron Homeostasis and Energy Metabolism in Obesity.Clinical nutrition research · 2022Review
- Iron and zinc homeostases in female rats with physically active and sedentary lifestyles.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Iron Deficiency and Anemia 10 Years After Roux-en-Y Gastric Bypass for Severe Obesity.Frontiers in endocrinology · 2021Observational
- Review
- Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity.Journal of inflammation (London, England) · 2020Article
- Article
- Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet.The Journal of nutritional biochemistry · 2020Article
- Iron Metabolism in Obesity and Metabolic Syndrome.International journal of molecular sciences · 2020Review
- Iron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Rats.Nutrients · 2019Article
- Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity has been reported to be associated with iron deficiency. However, few studies have investigated iron status in low adiposity. To investigate whether body adiposity was associated with altered hepatic iron status, we compared liver iron levels and markers involved in inflammation and iron absorption in obese, control, and mildly calorie restricted mice.
methodsSeven week old C57BL/6 mice were fed control (10% kcal fat, Control) or high fat (60% kcal fat, HFD) diets, or reduced amount of control diet to achieve 15% calorie restriction (CR) for 16 weeks. Hepatic non-heme iron content and ferritin protein level, and hematocrit and hemoglobin levels were determined to assess iron status. Hepatic expression of
resultsHepatic non-heme iron and ferritin protein levels were significantly higher in the CR group compared with the Control group, and significantly lower in the HFD group. These two iron status markers showed significantly negative correlations with the amount of white adipose tissue (
conclusionWe showed that body adiposity was inversely correlated with liver iron status. Low inflammation levels in hepatic milieu and enhanced expression of duodenal oxidoreductases induced by calorie restriction could have contributed to higher iron status.
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