ArticleIranian journal of pharmaceutical research : IJPR2016
A Search for Mitochondrial Damage in Alzheimer's Disease Using Isolated Rat Brain Mitochondria.
Article in Iranian journal of pharmaceutical research : IJPR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Vanillic Acid Mitigates Mitochondrial Dysfunction Induced by Lithium via Maintenance of Mitochondrial Function, Inhibition of Oxidative Stress, and Mitochondrial Swelling in Rat Heart-Isolated Mitochondria.Cardiovascular toxicology · 2025Article
- Mitochondrial Dysfunction in Neurodegenerative Diseases: Mechanisms and Corresponding Therapeutic Strategies.Biomedicines · 2025Review
- Association between Female Reproductive Factors and Risk of Dementia.Journal of clinical medicine · 2024Review
- Disentangling Mitochondria in Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Manganese (II) chloride leads to dopaminergic neurotoxicity by promoting mitophagy through BNIP3-mediated oxidative stress in SH-SY5Y cells.Cellular & molecular biology letters · 2021Article
- Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice.Molecular medicine reports · 2021Article
- Alzheimer's disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid.Metabolic brain disease · 2021Article
- Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits.Theranostics · 2021Article
- Multi-walled carbon nanotubes induce oxidative stress, apoptosis, and dysfunction in isolated rat heart mitochondria: protective effect of naringin.Environmental science and pollution research international · 2020Article
- Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases.Cytotechnology · 2019Review
- Leptin Modifies the Rat Heart Performance Associated with Mitochondrial Dysfunction Independently of Its Prohypertrophic Effects.International journal of endocrinology · 2018Article
- Anti-Oxidative Stress Activity Is Essential for Amanita caesarea Mediated Neuroprotection on Glutamate-Induced Apoptotic HT22 Cells and an Alzheimer's Disease Mouse Model.International journal of molecular sciences · 2017Article
- Repeated Administration of Mercury Intensifies Brain Damage in Multiple Sclerosis through Mitochondrial Dysfunction.Iranian journal of pharmaceutical research : IJPR · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one's physical surroundings. The pathological initiation and progression of AD is highly complex and its prevalence is on the rise. In his study, Alzheimer's disease was induced with single injection of amyloid-β (Aβ) peptides (30ng, by stereotaxy) in each hemisphere of the Wistar rat brain. Then memory dysfunction, oxidative stress and apoptosis induced by Aβ peptide were investigated on isolated brain mitochondria obtained from infected rat. Our results showed memory impairment in rats after receiving an Aβ peptide. We also found significant rise (P<0.05) at ROS formation, mitochondrial membrane depolarization, mitochondria swelling, cytochrome c release and significant decrease in ATP/ADP ratio on mitochondria isolated from brain of these memory impaired rats compared with those of untreated control rat group. Activation of caspase-3 the final mediator of apoptosis in the brain homogenate of the memory impaired rats was another justification for occurrence of neuron loss in the experimental model of AD. Our results suggest that oxidative stress and mitochondria mediated apoptosis in brain neurons play very important role in initiation of AD.
Indexed as
Identifiers
28228816PMC5242364W2301549389What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.