ArticleFrontiers in physiology2017
Increased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 48 citations in OpenAlex.
- Rhythms of growth: unveiling the mechanobiology behind heart maturation.The Journal of physiology · 2026Review
- A Parametric Finite Element Analysis of Chick Embryo Aortic Valve Leaflet Biomechanics.Bioengineering (Basel, Switzerland) · 2026Article
- An anatomically informed computational fluid dynamics modeling approach for quantifying hemodynamics in the developing heart.PloS one · 2025Article
- The Ongoing Relationship Between Offspring Congenital Heart Disease and Preeclampsia Across Pregnancies.JACC. Advances · 2024Article
- Automated endocardial cushion segmentation and cellularization quantification in developing hearts using optical coherence tomography.Biomedical optics express · 2022Article
- Effect of Blood Flow on Cardiac Morphogenesis and Formation of Congenital Heart Defects.Journal of cardiovascular development and disease · 2022Review
- Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling.PLoS biology · 2022Article
- Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves.Journal of cardiovascular development and disease · 2021Article
- Fetal Blood Flow and Genetic Mutations in Conotruncal Congenital Heart Disease.Journal of cardiovascular development and disease · 2021Review
- Mending a broken heart:Disease models & mechanisms · 2021Review
- Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies.Journal of cardiovascular development and disease · 2021Review
- ERBB3-dependent AKT and ERK pathways are essential for atrioventricular cushion development in mouse embryos.PloS one · 2021Article
- Angiogenesis in the Avian Embryo Chorioallantoic Membrane: A Perspective on Research Trends and a Case Study on Toxicant Vascular Effects.Journal of cardiovascular development and disease · 2020Review
- Semi-automated shear stress measurements in developing embryonic hearts.Biomedical optics express · 2020Article
- Mechanisms of heart valve development and disease.Development (Cambridge, England) · 2020Review
- Biomechanical Cues Direct Valvulogenesis.Journal of cardiovascular development and disease · 2020Review
- Organ Dynamics and Hemodynamic of the Whole HH25 Avian Embryonic Heart, Revealed by Ultrasound Biomicroscopy, Boundary Tracking, and Flow Simulations.Scientific reports · 2019Article
- Optical coherence tomography forBiomedical optics express · 2019Article
- Development and evolution of the metazoan heart.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Review
- Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation.JCI insight · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow to cardiac defects remain unclear. Endothelial-mesenchymal cell transition is one of the many complex developmental events involved in transforming the early embryonic outflow tract into the aorta, pulmonary trunk, interventricular septum, and semilunar valves. This study elucidated the effects of increased hemodynamic load on endothelial-mesenchymal transition remodeling of the outflow tract cushions
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.