Evidence map›Paper›PMID 28228602›Full record

ArticleScience translational medicine2017

A divergent population of autoantigen-responsive CD4

Anne-Kristin Heninger, Anne Eugster, Denise Kuehn, Florian Buettner, Matthias Kuhn, Annett Lindner, Sevina Dietz, Sibille Jergens, Carmen Wilhelm, Andreas Beyerlein and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

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  7. A minority of proliferating human CD4Frontiers in immunology · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Anne-Kristin HeningerDFG-Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.ORCID 0000-0003-3151-826X
Anne EugsterDFG-Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.ORCID 0000-0001-8009-5959
Denise KuehnDFG-Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.
Florian BuettnerEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, U.K.
Matthias KuhnInstitute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.ORCID 0000-0003-2868-5155
Annett LindnerDFG-Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.ORCID 0000-0002-2664-8994
Sevina DietzDFG-Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.ORCID 0000-0001-8360-7868
Sibille JergensInstitute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.ORCID 0000-0002-7061-8928
Carmen WilhelmDFG-Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.
Andreas BeyerleinInstitute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
Anette-G ZieglerInstitute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
Ezio BonifacioDFG-Center for Regenerative Therapies Dresden, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany. ezio.bonifacio@crt-dresden.de.ORCID 0000-0002-8704-4713
University Hospital Carl Gustav Carus · DETUM Klinikum · DEEuropean Bioinformatics Institute · GBHelmholtz Zentrum München · DETechnische Universität Dresden · DE

Funding

Medical Research Council MR/M01536X/1
6 · The paper itself

Abstract

Autoimmune diabetes is marked by sensitization to β cell self-antigens in childhood. We longitudinally followed at-risk children from infancy and performed single-cell gene expression in β cell antigen-responsive CD4

Indexed as

AutoimmunityAutoantibodiesAutoantigensCD4-Positive T-LymphocytesGene Expression ProfilingGlutamate DecarboxylaseHumansImmune ToleranceInfantInsulin-Secreting CellsTetanus ToxinTh1 CellsTranscription, GeneticAutoantibodiesAutoantigensGlutamate Decarboxylaseglutamate decarboxylase 2Tetanus Toxin

Identifiers

PMID28228602
OpenAlexW2589140426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.