Trial reportScience translational medicine2017
Antimicrobials from human skin commensal bacteria protect against
3 registry-linked trialsOpen access · greenAbstract readClinical Trial
In one paragraph
Trial report in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 595 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
595citing papers in PubMed, 1 pooled it
97.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registry for the Atopic Dermatitis Research Network (ADRN-02)
A Phase 1B Dose Escalating Study of the Safety, Short-Term Engraftment and Action of a Singly-Applied NB01 in Adults With Moderate Acne
Prospective Descriptive Study of the Cutaneous Microbiota of ICU Patients With Central Venous Catheter (ICMc)
Who cites it
595 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,056 citations in OpenAlex.
- Research hotspots and trends of skin barrier in atopic dermatitis in the past 24-year: a bibliometric analysis.Frontiers in medicine · 2025Pooled it
- S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double-blind randomized clinical trial in patients with mild to moderate atopic dermatitis.British journal of clinical pharmacology · 2026Trial
- Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor.Cell reports. Medicine · 2026Trial
- CERS1 is a biomarker of Staphylococcus aureus abundance and atopic dermatitis severity.The Journal of allergy and clinical immunology · 2025Trial
- Ceria-Based Nanotherapeutics for Inflammatory Skin Disorders: From Design and Mechanisms to Advanced Delivery and Future Perspectives.International journal of molecular sciences · 2026Review
- Gram-Positive and Gram-Negative Probiotic Extracellular Vesicles: Mechanisms of Immune Modulation and Therapeutic Opportunities in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2026Review
- Bacteriocins as Alternative Antimicrobial Agents for Wound-Associated Infections: Mechanisms, Activity Against Biofilms and Translational Potential.Antibiotics (Basel, Switzerland) · 2026Review
- Repression of Virulence in Staphylococcus aureus by 2-Aminothiol-Mediated Quorum Quenching.Angewandte Chemie (International ed. in English) · 2026Article
- From sequence space to ecological function: microbiome-derived antimicrobial peptides as community effectors and therapeutic leads.Essays in biochemistry · 2026Review
- Evaluating the potential of Cajanus cajan (L.) Millsp. Root to improve atopic dermatitis with different anti-inflammatory models and active compounds.Journal of food and drug analysis · 2026Article
- Current research landscape and future prospects of in silico modeling approaches for atopic dermatitis.JID innovations : skin science from molecules to population health · 2026Review
- Occupational Contact Dermatitis in the Post-COVID Era: From Barrier Dysfunction and Microbiome Dysbiosis to Prevention and Precision Management.Journal of clinical medicine · 2026Review
- ABPs: diffusible antibacterial toxins secreted by and active against diverse gram-positive bacteria.Infection and immunity · 2026Review
- Elucidating the Impact of Bacterial Composition and Diversity on Skin Homeostasis Using a Human 3D In Vitro Skin Model.Microorganisms · 2026Article
- A review of skin microbiome and new challenges to cosmetic microbiome-friendly formulations.International journal of cosmetic science · 2026Review
- Taxonomic and Functional Skin Microbiome Profiles in Nummular Eczema, Atopic Dermatitis, and Mixed Phenotypes: An Exploratory Shotgun Metagenomic Pilot Study.Microorganisms · 2026Article
- Atopic Dermatitis Beyond Cutaneous Inflammation: The Interplay Between Progesterone, Testosterone, Gut Microbiota, and Immune Dysregulation.Microorganisms · 2026Review
- Management of Infected, Non-Responsive Atopic Dermatitis in a Romanian Center.Journal of clinical medicine · 2026Article
- Changes in nasal and throat microbiota composition during and after mupirocin and chlorhexidine decolonization treatment in asymptomatic methicillin-resistant Staphylococcus aureus carriers: a longitudinal observational study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026Observational
- Review
535 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 1 country.
Teruaki NakatsujiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.ORCID 0000-0002-6187-2991
Tiffany H ChenDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.
Saisindhu NaralaDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.ORCID 0000-0001-9913-951X
Kimberly A ChunDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.
Aimee M TwoDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.
Tong YunDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.ORCID 0000-0003-2003-1843
Faiza ShafiqDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.ORCID 0000-0001-6211-7712
Paul F KotolDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.
Amina BouslimaniCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92092, USA.ORCID 0000-0002-1635-532X
Alexey V MelnikCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92092, USA.
Haythem LatifDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92092, USA.ORCID 0000-0001-5738-2802
Ji-Nu KimDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92092, USA.
Alexandre LockhartRho Federal Systems Division Inc., Chapel Hill, NC 27517, USA.
Keli ArtisRho Federal Systems Division Inc., Chapel Hill, NC 27517, USA.ORCID 0000-0002-7158-6382
Gloria DavidRho Federal Systems Division Inc., Chapel Hill, NC 27517, USA.
Patricia TaylorDivision of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
Joanne StreibDivision of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-9780-3437
Pieter C DorresteinCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92092, USA.ORCID 0000-0002-3003-1030
Alex GrierDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY 14611, USA.
Steven R GillDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY 14611, USA.ORCID 0000-0002-2408-1373
Karsten ZenglerDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92092, USA.
Tissa R HataDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.
Donald Y M LeungDivision of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
Richard L GalloDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA. rgallo@ucsd.edu.ORCID 0000-0002-1401-7861
University of California San Diego · USLa Jolla Bioengineering Institute · USNational Jewish Health · USRho (United States) · USUniversity of Montana · USUniversity of Rochester · US
Funding
Transplantation GroupUM2AI117870 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI DAVID, GLORIA · 2015 to 2023
$208.1MTargeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI GEHA, RAIF SALIM · 2015 to 2019
$30.6MSEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0MCathelicidins in Skin ImmunityR01AI052453 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI GALLO, RICHARD L, NIZET, VICTOR · 2002 to 2017
$5.3MUC San Diego Clinical and Translational Research InstituteTL1TR001443 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2019
$3.4MSkin Barrier and the MicrobiomeR01AR064781 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, HATA, TISSA R · 2014 to 2018
$1.8MSkin barrier function and the microbiomeR01AI116576 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, NAKATSUJI, TERUAKI · 2015 to 2019
$1.7MEstablishing a Skin Microbiome TransplantR21AR067547 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, HATA, TISSA R · 2015 to 2016
$375kNCATS NIH HHS TL1 TR001443NIAID NIH HHS R01 AI052453NIAID NIH HHS R01 AI116576NIAID NIH HHS U01 AI147462NIAID NIH HHS U19 AI117673NIAID NIH HHS UM2 AI117870NIAMS NIH HHS R01 AR064781NIAMS NIH HHS R21 AR067547
Abstract
The microbiome can promote or disrupt human health by influencing both adaptive and innate immune functions. We tested whether bacteria that normally reside on human skin participate in host defense by killing
Indexed as
Amino Acid SequenceAnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesBacteriaCoagulaseColony Count, MicrobialDermatitis, AtopicDysbiosisHumansMiceMicrobiotaSkinStaphylococcus aureusSus scrofaAnti-Infective AgentsAntimicrobial Cationic PeptidesCoagulase
Identifiers
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Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.