ArticleProceedings of the National Academy of Sciences of the United States of America2017
Chirality-induced spin polarization places symmetry constraints on biomolecular interactions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 212 citations in OpenAlex.
- Role of stereochemistry on electron transport in peptides.bioRxiv : the preprint server for biology · 2026Article
- Chirality-Induced Orbital-Angular-Momentum Selectivity in Electron Transmission and Scattering.Journal of chemical theory and computation · 2026Article
- Controlling Amyloid Assembly Dynamics Using Spin Interfaces.ACS nano · 2025Article
- Possible Enantioseparation of Racemic Ribose on Chiral Surface Formed by Adsorption of Nucleobases.Life (Basel, Switzerland) · 2025Article
- Highly enantioselective synthesis controlled by spin-exchange interaction.Science advances · 2025Article
- Chirality-Induced Spin Selectivity at the Molecular Level: A Different Perspective to Understand and Exploit the Phenomenon.The journal of physical chemistry letters · 2025Review
- Article
- Role of Electron Spin, Chirality, and Charge Dynamics in Promoting the Persistence of Nascent Nucleic Acid-Peptide Complexes.The journal of physical chemistry. B · 2025Article
- What Can CISS Teach Us about Electron Transfer?The journal of physical chemistry letters · 2024Review
- Approaches for Positioning the Active Medium in Hybrid Nanoplasmonics. Focus on Plasmon-Assisted Photopolymerization.ACS photonics · 2024Review
- A chemical perspective on the chiral induced spin selectivity effect.National science review · 2024Review
- Proton Conduction in Chiral Molecular Assemblies of Azolium-Camphorsulfonate Salts.Journal of the American Chemical Society · 2024Article
- Chiral Molecular Coating of a LiNiCoMnOThe journal of physical chemistry letters · 2024Article
- Chiral Induced Spin Selectivity.Chemical reviews · 2024Review
- Quantum Biology and the Potential Role of Entanglement and Tunneling in Non-Targeted Effects of Ionizing Radiation: A Review and Proposed Model.International journal of molecular sciences · 2023Review
- Detection of a Chirality-Induced Spin Selective Quantum Capacitance in α-Helical Peptides.Nano letters · 2023Article
- A quantum physics layer of epigenetics: a hypothesis deduced from charge transfer and chirality-induced spin selectivity of DNA.Clinical epigenetics · 2023Article
- Beyond Stereoisomeric Effects: Exploring the Importance of Intermolecular Electron Spin Interactions in Biorecognition.The journal of physical chemistry letters · 2023Article
- Examining the Effects of Homochirality for Electron Transfer in Protein Assemblies.The journal of physical chemistry. B · 2023Article
- Spin-Based Chiral Separations and the Importance of Molecule-Solvent Interactions.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noncovalent interactions between molecules are key for many biological processes. Necessarily, when molecules interact, the electronic charge in each of them is redistributed. Here, we show experimentally that, in chiral molecules, charge redistribution is accompanied by spin polarization. We describe how this spin polarization adds an enantioselective term to the forces, so that homochiral interaction energies differ from heterochiral ones. The spin polarization was measured by using a modified Hall effect device. An electric field that is applied along the molecules causes charge redistribution, and for chiral molecules, a Hall voltage is measured that indicates the spin polarization. Based on this observation, we conjecture that the spin polarization enforces symmetry constraints on the biorecognition process between two chiral molecules, and we describe how these constraints can lead to selectivity in the interaction between enantiomers based on their handedness. Model quantum chemistry calculations that rigorously enforce these constraints show that the interaction energy for methyl groups on homochiral molecules differs significantly from that found for heterochiral molecules at van der Waals contact and shorter (i.e., ∼0.5 kcal/mol at 0.26 nm).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.