Evidence map›Paper›PMID 28228453›Full record

Observational studyCirculation. Cardiovascular quality and outcomes2017

Impaired Health Status, Psychological Distress, and Personality in Women and Men With Nonobstructive Coronary Artery Disease: Sex and Gender Differences: The TWIST (Tweesteden Mild Stenosis) Study.

Paula M C Mommersteeg, Lindy Arts, Wobbe Zijlstra, Jos W Widdershoven, Wilbert Aarnoudse, Johan Denollet

Erratum issued Registry-linked trialOpen access · greenAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Cardiovascular quality and outcomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01788241 (A Psycho-biochemical Perspective on Non-significant Coronary Artery Disease), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01788241 unknown statusnot on this map

A Psycho-biochemical Perspective on Non-significant Coronary Artery Disease: a Prospective Cohort Study of Classic and Novel Risk Markers.

TypeobservationalSponsorTilburg UniversityRan2009 to 2025Enrolled547ConditionsCoronary Artery Disease, Non-significant Coronary Artery Disease, Mild Stenosis, Vascular Irregularities
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Higher anxiety score in patients with non-obstructive coronary artery disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Cardiac medication use in patients with suspected ischaemia without obstructive coronary arteries: sex differences and psychological distress.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021
    Article
  7. Article
  8. Article
  9. Sex, Lies, and Coronary Artery Disease.Journal of clinical medicine · 2021
    Article
  10. Article
  11. Using path analysis to investigate the relationships between depression, anxiety, and health-related quality of life among patients with coronary artery disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
    Article
  12. Article
  13. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Paula M C MommersteegFrom the Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, The Netherlands (P.M.C.M., L.A, W.Z., J.W., J.D.); and Department of Cardiology, Elisabeth-Tweesteden Hospital, The Netherlands (J.W., W.A.). P.M.C.Mommersteeg@uvt.nl.
Lindy ArtsFrom the Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, The Netherlands (P.M.C.M., L.A, W.Z., J.W., J.D.); and Department of Cardiology, Elisabeth-Tweesteden Hospital, The Netherlands (J.W., W.A.).
Wobbe ZijlstraFrom the Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, The Netherlands (P.M.C.M., L.A, W.Z., J.W., J.D.); and Department of Cardiology, Elisabeth-Tweesteden Hospital, The Netherlands (J.W., W.A.).
Jos W WiddershovenFrom the Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, The Netherlands (P.M.C.M., L.A, W.Z., J.W., J.D.); and Department of Cardiology, Elisabeth-Tweesteden Hospital, The Netherlands (J.W., W.A.).
Wilbert AarnoudseFrom the Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, The Netherlands (P.M.C.M., L.A, W.Z., J.W., J.D.); and Department of Cardiology, Elisabeth-Tweesteden Hospital, The Netherlands (J.W., W.A.).
Johan DenolletFrom the Center of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, The Netherlands (P.M.C.M., L.A, W.Z., J.W., J.D.); and Department of Cardiology, Elisabeth-Tweesteden Hospital, The Netherlands (J.W., W.A.).
Elisabeth-TweeSteden Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with nonobstructive coronary artery disease (NOCAD; wall irregularities, stenosis <60%), and women with NOCAD in particular, remain underinvestigated. We examined sex and gender (S&G) differences in health status, psychological distress, and personality between patients with NOCAD and the general population, as well as S&G differences within the NOCAD population. METHODS AND

resultsIn total, 523 patients with NOCAD (61±9 years, 52% women) were included via coronary angiography and computed tomography as part of the TWIST (Tweesteden Mild Stenosis) study. Generic health status (12-item Short Form physical and mental scales and fatigue), psychological distress (Hospital Anxiety and Depression Scale anxiety and depressive symptoms and Global Mood Scale negative and positive affect), and personality (Type D personality) were compared between patients with NOCAD and an age- and sex-matched group of 1347 people from the general population. Frequency matching was performed to obtain a similar sex distribution in each age-decile group. Both men and women with NOCAD reported impaired health status, more psychological distress, and Type D personality compared with men and women in the reference group. Women reported more psychosocial distress compared with men, but no significant sex-by-group interaction effects were observed. Women with NOCAD reported impaired health status, more anxiety, and less positive affect, but no differences in depressive symptoms, angina, or Type D personality when compared with men with NOCAD. Age, education, employment, partner, and alcohol use explained these S&G differences within the NOCAD group.

conclusionsIn both men and women, NOCAD was associated with impaired health status, more psychological distress, and Type D personality when compared with a reference population. Factors reflecting S&G differences explained these S&G findings in patient-reported outcomes. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01788241.

Indexed as

Health Status DisparitiesPersonalityAgedAge DistributionAge FactorsAnxietyCase-Control StudiesComorbidityComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisDepressionFemaleHumansMaleanxietycoronary artery diseasedepressionhealth statusquality of lifesexType D personality

Identifiers

PMID28228453
PMCPMC5333724
OpenAlexW2589611129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.