Trial reportThe American journal of clinical nutrition2017
Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.
Abstract readRandomized Controlled Trial
In one paragraph
Trial report in The American journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Self-selected dietary intake and association with achieved caloric restriction in CALERIECritical reviews in food science and nutrition · 2026Trial
- Association between physical activity energy expenditure and markers of healthspan during prolonged calorie restriction in individuals without obesity: observations from the CALERIE™ phase 2 randomized controlled trial.The international journal of behavioral nutrition and physical activity · 2025Trial
- Effect of caloric restriction on organ size and its contribution to metabolic adaptation: an ancillary analysis of CALERIE 2.Scientific reports · 2025Trial
- Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial.Obesity (Silver Spring, Md.) · 2025Trial
- The CALERIE Genomic Data Resource.Nature aging · 2025Trial
- Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.Nature aging · 2023Trial
- Body shape perception in men and women without obesity during caloric restriction: a secondary analysis from the CALERIE study.Eating and weight disorders : EWD · 2023Trial
- Challenges in defining successful adherence to calorie restriction goals in humans: Results from CALERIE™ 2.Experimental gerontology · 2022Trial
- Modestly Increased Incidence of Ketosis in Caloric Restriction Does not Significantly Alter the Effects of Caloric Restriction.The journal of nutrition, health & aging · 2022Trial
- Is muscle and protein loss relevant in long-term fasting in healthy men? A prospective trial on physiological adaptations.Journal of cachexia, sarcopenia and muscle · 2021Trial
- Effect of 2-year caloric restriction on organ and tissue size in nonobese 21- to 50-year-old adults in a randomized clinical trial: the CALERIE study.The American journal of clinical nutrition · 2021Trial
- Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.Nutrition reviews · 2021Trial
- Trial
- Change in self-efficacy, eating behaviors and food cravings during two years of calorie restriction in humans without obesity.Appetite · 2019Trial
- 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.The lancet. Diabetes & endocrinology · 2019Trial
- Significant improvement in cardiometabolic health in healthy nonobese individuals during caloric restriction-induced weight loss and weight loss maintenance.American journal of physiology. Endocrinology and metabolism · 2018Trial
- Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength.Medicine and science in sports and exercise · 2017Trial
- Clinical Protocol for the Dietary Approaches to Longevity and Health (DiAL Health) Pilot Trial.Current developments in nutrition · 2026Article
- Risk of protein intake deficiency during treatment with GLP-1 and GIP/GLP-1 receptor agonists: considerations for secondary sarcopenia.Advances in therapy · 2026Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Sai Krupa DasJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA; sai.das@tufts.edu.ORCID 0000-0003-0788-0461
Susan B RobertsJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
Manjushri V BhapkarDuke Clinical Research Institute and Duke University Medical Center, Durham, NC.ORCID 0000-0001-5388-600X
Dennis T VillarealWashington University School of Medicine, St Louis, MO.ORCID 0000-0003-1365-7960
Luigi FontanaCEINGE Biotecnologie Avanzate, Napoli, Italy.ORCID 0000-0002-3626-1195
Corby K MartinPennington Biomedical Research Center, Baton Rouge, LA.ORCID 0000-0002-8125-4015
Susan B RacetteWashington University School of Medicine, St Louis, MO.ORCID 0000-0002-6932-1887
Paul J FussJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.ORCID 0000-0002-9085-8558
William E KrausDuke Clinical Research Institute and Duke University Medical Center, Durham, NC.ORCID 0000-0003-1930-9684
William W WongUSDA/Agricultural Research Services, Children's Nutrition Research Center at Baylor College of Medicine, Houston, TX; and.ORCID 0000-0002-7147-5850
Edward SaltzmanJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.ORCID 0000-0002-3626-1195
Carl F PieperDuke Clinical Research Institute and Duke University Medical Center, Durham, NC.ORCID 0000-0003-4809-1725
Roger A FieldingJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.ORCID 0000-0003-2236-9020
Ann V SchwartzUniversity of California, San Francisco, CA.ORCID 0000-0003-4529-1641
Eric RavussinPennington Biomedical Research Center, Baton Rouge, LA.ORCID 0000-0003-2129-547X
Leanne M RedmanPennington Biomedical Research Center, Baton Rouge, LA.ORCID 0000-0002-7267-7374
CALERIE-2 Study Group
Funding
Coordinating Center for CALERIEU01AG022132 · NIA · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2002 to 2013
$24.9MMetabolic Adaptations to Two Year Caloric RestrictionU01AG020478 · NIA · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RAVUSSIN, ERIC · 2002 to 2008
$13.4MCaloric Restriction and Aging in HumansU01AG020487 · NIA · WASHINGTON UNIVERSITY · PI HOLLOSZY, JOHN O. · 2001 to 2009
$8.9MDietary Energy Restriction and Metabolic Aging in HumansU01AG020480 · NIA · TUFTS UNIVERSITY BOSTON · PI ROBERTS, SUSAN B · 2002 to 2008
$8.2MBiomarkers of Caloric Restriction in Humans: the CALERIE BiorepositoryU24AG047121 · NIA · DUKE UNIVERSITY · PI KRAUS, WILLIAM E, PIEPER, CARL F · 2015 to 2019
$3.2MNIA NIH HHS U01 AG020478NIA NIH HHS U01 AG020480NIA NIH HHS U01 AG020487NIA NIH HHS U01 AG022132NIA NIH HHS U24 AG047121
Abstract
PubMed holds no abstract for this paper.
Indexed as
Body CompositionBody Mass IndexCaloric RestrictionEnergy IntakeWeight LossAdipose TissueAdiposityAdultBody Fluid CompartmentsBody WeightDietEnergy MetabolismFemaleHumansLongevityMalebody compositioncalorie restrictionhumanslong-termnonobese
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.