Evidence map›Paper›PMID 28228416›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017

Cough and expiration reflexes elicited by inhaled irritant gases are intensified in ovalbumin-sensitized mice.

Cheng Zhang, Ruei-Lung Lin, Jeff Hong, Mehdi Khosravi, Lu-Yuan Lee

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Mechanisms of bacterial host-to-host transmission.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Release of ATP in the lung evoked by inhalation of irritant gases in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  6. Identifying vagal bronchopulmonary afferents mediating cough response to inhaled sulfur dioxide in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Non-primate animal models for pertussis: back to the drawing board?Applied microbiology and biotechnology · 2022
    Review
  11. Article
  12. Article
  13. Cough responses to inhaled irritants are enhanced by eosinophil major basic protein in awake mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
  14. Article
  15. Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Cheng ZhangDepartment of Physiology, University of Kentucky, Lexington, Kentucky.
Ruei-Lung LinDepartment of Physiology, University of Kentucky, Lexington, Kentucky.
Jeff HongDepartment of Physiology, University of Kentucky, Lexington, Kentucky.
Mehdi KhosraviDepartment of Medicine, University of Kentucky, Lexington, Kentucky; and.
Lu-Yuan LeeDepartment of Physiology, University of Kentucky, Lexington, Kentucky; lylee@uky.edu.
University of Kentucky · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
NCATS NIH HHS UL1 TR001998
6 · The paper itself

Abstract

This study was designed to determine the effect of active sensitization with ovalbumin (Ova) on cough responses to inhaled irritant gases in mice. Conscious mice moved freely in a recording chamber, while the pressure change in the chamber and audio and video signals of the mouse movements were recorded simultaneously to measure the frequencies of cough reflex (CR) and expiration reflex (ER). To further verify the accuracy of cough analysis, the intrapleural pressure was also recorded by a telemetry sensor surgically implanted in the intrapleural space in a subgroup of mice. During the irritant gas inhalation challenge, sulfur dioxide (SO

Indexed as

Administration, InhalationAmmoniaAnimalsCoughExhalationInhalation ExposureIrritantsLung InjuryMaleMiceMice, Inbred C57BLOvalbuminPneumoniaReflexReflex, AbnormalSulfur DioxideAmmoniaIrritantsOvalbuminSulfur DioxideVehicle Emissionsairwayallergen coughinflammationinhaled irritants

Identifiers

PMID28228416
PMCPMC5451571
OpenAlexW2590948739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.