ArticleIndian heart journal
Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: A study from northern India.
Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 51 citations in OpenAlex.
- Addressing micronutrient deficiencies and vitamin metabolism disorders in pediatric pulmonary hypertension: a strategic proposal for low- and middle-income countries.Frontiers in cardiovascular medicine · 2026Review
- Fulminant Thiamine Deficiency in An Infant.Indian journal of pediatrics · 2025Article
- The Pivotal Role of Thiamine Supplementation in Counteracting Cardiometabolic Dysfunctions Associated with Thiamine Deficiency.International journal of molecular sciences · 2025Review
- Thiamine: An indispensable regulator of paediatric neuro-cardiovascular health and diseases.European journal of pediatrics · 2024Review
- The role of CT brain findings in the early diagnosis of infantile encephalitic beriberi.Neuroradiology · 2024Article
- A Predictive Model for Thiamine Responsive Disorders Among Infants and Young Children: Results from a Prospective Cohort Study in Lao People's Democratic Republic.The Journal of pediatrics · 2024Article
- Thiamine responsive high output heart failure of adults: an under-recognized entity.European journal of clinical nutrition · 2023Article
- Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency.PLoS neglected tropical diseases · 2023Article
- Vitamin B1 Deficiency and Perimyocarditis Fulminans: A Case Study of Shoshin Syndrome in a Woman Following an Unbalanced Dietary Pattern Followed by a Literature Review.Life (Basel, Switzerland) · 2023Article
- Thiamine deficiency in pregnancy and lactation: implications and present perspectives.Frontiers in nutrition · 2023Review
- An Overview of Type B Lactic Acidosis Due to Thiamine (B1) Deficiency.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Article
- Thiamine deficiency disorders: a clinical perspective.Annals of the New York Academy of Sciences · 2021Review
- Pediatric thiamine deficiency disorders in high-income countries between 2000 and 2020: a clinical reappraisal.Annals of the New York Academy of Sciences · 2021Review
- Infantile thiamine deficiency in South and Southeast Asia: An age-old problem needing new solutions.Nutrition bulletin · 2021Review
- Thiamine-Responsive Acute Pulmonary Hypertension of Early Infancy (TRAPHEI)-A Case Series and Clinical Review.Children (Basel, Switzerland) · 2020Review
- Infantile Cardiac Beriberi in Rural North East India.Indian pediatrics · 2020Article
- Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs.Annals of the New York Academy of Sciences · 2018Article
- CSI position statement on management of heart failure in India.Indian heart journal · 2018Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the effect of thiamine administration on the resolution of pulmonary hypertension in exclusively breastfed infants.
designProspective cohort study.
settingHospital based study of a tertiary care hospital. PATIENTS: A total of 29 infants with 17 males (58.6%) and 12 females (41.4%) were included in the study.
interventionIn addition to the management of shock, right heart failure and renal failure, patients received intravenous thiamine 100mg/kg IV followed by 10mg/day till introduction of supplementary feeds. MAIN OUTCOMES MEASURES: Resolution of shock, metabolic complications and pulmonary hypertension.
resultsMean age at presentation was 78.45±30.7 days. All infants were exclusively breastfed. 86.2% of mothers were on customary dietary restrictions. Biventricular failure and tachycardia was commonly present. There were four deaths in our series. Acute metabolic acidosis was a universal feature with a mean pH of 7.21±0.15. Pulmonary hypertension was present in all patients on admission. Intravenous thiamine 100mg/kg IV stat was given immediately after documenting pulmonary hypertension. Repeat echocardiography showed complete resolution of pulmonary hypertension.
conclusionMany infants present to us with Shoshin beriberi with unusually high pulmonary pressures. These patients respond to thiamine challenge with prompt resolution of metabolic complications and reversal of pulmonary hypertension. We believe this is first of its kind from the region, which is reported.
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